Expression of CD147, MMP-9 and HER-2 in patients with gastric cancer and their correlation with clinicopathology and prognosis
10.3760/cma.j.issn.1008-6706.2019.22.002
- VernacularTitle: 胃癌组织中细胞外基质金属蛋白酶诱导因子、基质金属蛋白酶9、人表皮生长因子受体2表达与患者临床特征及预后的相关性研究
- Author:
Binghui LIU
1
;
Bing PAN
Author Information
1. Department of Pathology, the First People's Hospital of Taizhou, Taizhou, Zhejiang 318020, China
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Paracancerous tissue of gastric mucosa;
Extracellular matrix metalloproteinase-inducing factor;
Matrix metalloproteinase-9;
Human epidermal growth factor receptor-2;
Tumor diameter;
Differentiation degree;
Lymph node metastasis;
Prognosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(22):2694-2698
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between the expression of extracellular matrix metalloproteinase-inducible factor (CD147), matrix metalloproteinase-9 (MMP-9) and human epidermal growth factor receptor-2 (HER-2) in gastric cancer tissues and clinical pathology and prognosis.
Methods:From June 2016 to June 2018, 80 gastric cancer specimens from the First People's Hospital of Taizhou were collected as observation group, and another 60 normal specimens of gastric mucosa adjacent to cancer were selected as control group.The expressions of CD147, MMP-9 and HER-2 were detected by SP immunohistochemical method.The positive rates of CD147, MMP-9 and HER-2 protein expression, the positive rates of CD147, MMP-9 and HER-2 protein expression in different pathological characteristics, and the positive rates of CD147, MMP-9 and HER-2 protein expression in different prognosis were compared between the two groups.
Results:The positive rates of CD147 (73.75%), MMP-9 (76.25%) and HER-2 (42.50%) in the observation group were higher than those in the control group (21.67%, 25.00%, 5.00%), the differences were statistically significant (χ2=37.233, 36.288, 24.797, all P<0.05). There were no statisticallysignificant differences in the positive expression rates of CD147, MMP-9 and HER-2 protein among different gender, age, tumor diameter and differentiation (all P>0.05). The positive rates of CD147 (93.88%), MMP-9 (95.92%) and HER-2 (61.22%) with lymph node metastasis were higher than those without lymph node metastasis (41.94%, 45.16%, 12.90%), the differences were statistically significant (χ2=26.462, 27.012, 18.142, all P<0.05). The positive rates of CD147 (96.15%), MMP-9 (92.31%) and HER-2 (69.23%) in the death group were higher than those in the survival group (62.96%, 68.52%, 29.63%), the differences were statistically significant(χ2=9.987, 5.484, 11.263, all P<0.05).
Conclusion:High expression of CD147, MMP-9 and HER-2 proteins in gastric cancer tissues is closely related to invasion and metastasis, which can become a new prognostic marker and therapeutic target of gastric cancer.
