Expression of integrin β3 in the endometrial implantation window of patients with cesarean section scar infertility and its correlation with endometrial receptivity
10.3760/cma.j.issn.1008-6706.2019.21.015
- VernacularTitle: 整合素β3在剖宫产瘢痕憩室不孕患者种植窗期子宫内膜中的表达及其与子宫内膜容受性的相关性
- Author:
Meifang ZHOU
1
;
Pingsheng CAI
1
;
Haixian ZHOU
1
;
Lihe ZHU
2
Author Information
1. Department of Obstetrics and Gynecology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China
2. Department of Pathology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China
- Publication Type:Journal Article
- Keywords:
Infertility;
Cesarean section;
Cicatrix;
Fertile period;
Endometrial receptivity;
Integrin beta3
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(21):2627-2630
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of integrin β3 in the endometrial implantation window of patients with cesarean scar and infertility, and its correlation with endometrial receptivity.
Methods:A total of 40 patients with previous cesarean scar defect (PCSD) secondary infertility treated in Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from April 2018 to December 2019 were enrolled as the observation group.The natural cycle of 40 normal women who were examined in our hospital at the same time were selected as the control group.The two groups were enrolled in the endometrium of the glandular epithelial cells for MMP-9, TIMP-1 and LIF immunohistochemical staining, and statistical analysis was performed.The serum E2 and P levels of the implantation group were compared.The E2/P ratio was measured and compared, and the expression level of integrin β3 endometrial planting window was compared.
Results:The MMP-9, TIMP-1 and LIF in the observation group [(175.31±56.36), (201.46±51.34), (209.23±45.23)] were significantly lower than those in the control group [(252.35±78.43), (257.23±74.13), (298.34±72.35)] (t=5.334, 5.766, 6.023, all P<0.05), but the E2, P and E2/P in the observation group [(515.31±56.36)pmol/L, (53.71±8.34)pmol/L, (13.23±5.23)] were higher than those in the control group[(352.35±78.43)pmol/L, (33.13±4.13)pmol/L, (8.17±2.91)] (t=7.334, 4.251, 3.241, all P<0.05). The level of beta 3 in the observation group (0.163±0.013) was significantly lower than that in the control group (0.253±0.031) (t=4.342, P<0.05). The thickness of endometrium in the observation group [(9.12±2.03)mm] was significantly thinner than that in the control group [(12.24±2.45)mm] (t=3.226, P<0.05).
Conclusion:The expression of integrin β3 in the endometrial implantation window of patients with cesarean section scar infertility has a certain influence on endometrial receptivity.
