Distribution of serum creatinine and establishment of reference interval in healthy adults of Lianyungang, Jiangsu province
10.3760/cma.j.issn.1008-6706.2019.21.014
- VernacularTitle: 江苏省连云港市健康成年人血清肌酐浓度的分布及其参考区间的建立
- Author:
Fumeng YANG
1
;
Qian LIU
;
Shun WANG
;
Jin SUN
;
Li YAO
;
Mei FU
;
Wenjun WANG
;
Wei LIANG
Author Information
1. Department of Clinical Laboratory, the Second People's Hospital of Lianyungang, Lianyungang, Jiangsu 222006, China
- Publication Type:Journal Article
- Keywords:
Creatinine;
Gender;
Age;
Reference interval
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(21):2622-2626
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To preliminarily establish the reference interval for serum creatinine in healthy adults aged 20-79 years in city of Lianyungang.
Methods:A total of 34 577 cases of reference individuals were selected from physical examination population by using the principle of complete randomization, and the concentration of serum creatinine was detected by AU5821 automatic biochemical analyzer with its matching reagents.According to the standards of CLSI C28-A3 and WS/T 402-2012 " Clinical Laboratory Test Project Reference Interval Formulation" , the reference interval of serum creatinine was established.
Results:There was statistically significant difference of serum creatinine in gender and age between healthy adults in this area (male group: 78[72-84]μmol/L, female group: 61[56-66]μmol/L; aged 20-59 of male group: 78[72-84]μmol/L, aged 60-79 of male group: 77[70-85]μmol/L; aged 20-59 of female group: 60[56-65]μmol/L, aged 60-79 of female group: 63[58-69]μmol/L) (Z=120.93, Z=31.53, Z=28.45; all P<0.05). Therefore, the reference interval of serum creatinine was established based on gender and age, and its reference interval was 61-97μmol/L (aged 20-59 of male), 60-106μmol/L (aged 60-79 of male), 47-76μmol/L (aged 20-59 of female) and 49-86μmol/L (aged 60-79 of female), respectively.
Conclusion:Establishment of reference interval in serum creatinine plays an important role in the auxiliary diagnosis, progression and prognosis evaluation of various kidney diseases.
