Anesthetic effect of sufentanil combined with propofol in different target-controlled concentrations in patients with breast cancer
10.3760/cma.j.issn.1008-6706.2019.21.013
- VernacularTitle: 不同靶控浓度舒芬太尼复合丙泊酚用于乳腺癌手术的麻醉效果比较
- Author:
Rong HU
1
;
Haiyan WENG
;
Li CAI
Author Information
1. Department of Anesthesiology, the Maternal and Child Health Hospital of Cixi, Cixi, Zhejiang 315300, China
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Mastectomy;
Anesthetic, intravenous;
Arterial pressure;
Heart rate;
Blood oxygen saturation;
Recovery time;
Sufentanil;
Propofol
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(21):2617-2621
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the anesthetic effect of sufentanil combined with propofol with different target control concentration for breast cancer patients.
Methods:From January 10, 2015 to December 20, 2017, according to the digital table, 80 patients with breast cancer in the Maternal and Child Health Hospital of Cixi were randomly divided into three groups: group A(28 cases, the intraoperative sufentanil plasma target control concentration was 0.2ng/mL), group B (27 cases, the intraoperative sufentanil plasma target control concentration was 0.4ng/mL), group C (24 cases, the intraoperative sufentanil plasma target control concentration was 0.8ng/mL). The plasma target control concentration of propofol in three groups was 3μg/mL.The hemodynamic level[mean arterial pressure(MAP), heart rate(HR)], blood oxygen saturation(SpO2), recovery time, respiratory recovery time and incidence of adverse reactions were compared among the three groups.
Results:The MAP of T2, T3 and T4 in group A, group B and group C[T2: (78.56±7.42)mmHg vs.(76.98±7.65)mmHg vs.(69.36±7.69)mmHg; T3: (88.24±7.61)mmHg vs.(86.95±7.59)mmHg vs.(69.41±7.70)mmHg; T4: (72.32±7.51)mmHg vs.(69.24±7.21)mmHg vs.(66.52±6.85)mmHg], HR[T2: (73.65±8.75)times/min vs.(73.49±8.69)times/min vs.(68.36±7.79)times/min; T3: (76.75±8.95)times/min vs.(75.58±7.96)times/min vs.(68.65±7.36)times/min; T4: (71.42±7.41)times/min vs.(70.24±6.49)times/min vs.(64.39±6.62)times/min] showed significant differences[F(MAP)= 8.524, 15.365, 5.325; F(HR)=8.104, 12.521, 5.015, all P<0.05]. However, there were no statistically significant differences in SpO2 among group A, group B and group C in T2, T3 and T4(all P>0.05). There were no statistically significant differences in resuscitation time and respiratory recovery time among group A, group B and group C (all P>0.05). There was no statistically significant difference in the incidence of adverse reactions among group A, group B and group C(P>0.05).
Conclusion:0.8ng/mL sufentanil combined with 3μg/mL propofol has better anesthetic effect on patients undergoing breast cancer surgery, which is helpful to maintain hemodynamic stability.
