Effect of doxofylline on acute exacerbation of chronic obstructive pulmonary disease in convalescent stage
10.3760/cma.j.issn.1008-6706.2019.21.007
- VernacularTitle: 多索茶碱用于慢性阻塞性肺疾病急性加重恢复期的效果观察
- Author:
Xueping ZHANG
1
;
Ying ZHANG
;
Xiaofen MA
;
Xin LI
;
Zhencai HU
;
Yunqing ZHAI
Author Information
1. Department of Respiratory Medicine, Binzhou Central Hospital, Binzhou, Shandong 251700, China
- Publication Type:Journal Article
- Keywords:
Pulmonary disease, chronic obstructive;
Forced expiratory volume;
Doxofylline
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(21):2588-2592
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of doxofylline on acute exacerbation of chronic obstructive pulmonary disease (COPD) and reduce the risk of early recurrence.
Methods:From January 2016 to January 2018, 164 patients with acute exacerbation of COPD in Binzhou Central Hospital were randomly divided into two groups by random digital table: control group (n=82) and observation group (n=82). The control group was given tiotropium bromide and budesonide/formoterol.The observation group was treated with oral doxophylline bid for 8 weeks on the basis of inhaled drugs.The recovery time, acute exacerbation rate, FEV1, CAT score and 6-minute walking test were compared between the two groups.
Results:The time of convalescent stage in the observation group was shorter than that in the control group[(16.89±5.15)d vs.(19.12±6.29)d, t=2.48, P=0.014], and the acute exacerbation rate of the observation group was lower than that of the control group (26.83% vs.41.46%, χ2=4.58, P=0.032). There was no statistically significant difference in FEV1[(45.59±9.82)% vs.(44.26±9.03)%, t=0.90, P=0.369], and the CAT score of the observation group was better than that of the control group [(19.32±6.16)points vs.(21.71±6.62)points, t=2.39, P=0.018]. The 6-minute walking distance of the observation group was longer than that of the control group[(146.32±10.20)m vs.(135.69±11.59)m, t=6.23, P=0.000], and the finger pulse oxygen of the observation group was higher than that of the control group[(94.12±5.09)% vs.(92.06±6.21)%, t=2.23, P=0.026]. The respiratory rate in the observation group was slower than that in the control group[(20.38±7.32)times/min vs.(22.86±6.53)times/min, t=2.29, P=0.023], and there was no statistically significant difference in heart rate[(98.24±12.35)bpm vs.(101.38±15.03)bpm, t=1.46, P=0.146]. No serious adverse drug reactions were found in both two groups.
Conclusion:As a beneficial supplement of inhaled drugs in convalescent COPD, doxofylline can shorten the recovery time, reduce the early acute exacerbation rate and improve the symptoms, which is worthy of clinical reference.
