Efficacy of Linglianhu granule in the treatment of depression after coronary heart disease with syndrome of heart-kidney imbalance and its effect on serum levels of inflammatory factors and neurotransmitters
10.3760/cma.j.issn.1008-6706.2019.20.004
- VernacularTitle: 灵莲花颗粒对冠心病合并抑郁症心肾不交证的疗效及血清炎性因子和神经递质水平的影响
- Author:
Xiaocai LIU
1
;
Kangning LI
1
;
Yuandong MA
1
Author Information
1. Department of Psychiatry, Kangning Hospital Affiliated to Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Depression;
Syndrome of heart-kidney imbalance;
Interleukin-8;
Interleukin-17;
Norepinephrine;
Serotonin;
Linglianhua grain
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(20):2446-2450
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of Linglianhua granule in the treatment of depression after coronary heart disease with syndrome of heart-kidney imbalance and its effect on serum levels of interleukin(IL)-8, IL-17, norepinephrine(NE), and 5-hydroxytryptamine(5-HT).
Methods:From December 2016 to December 2018, 260 cases with depression after coronary heart disease were selected in Kangning Hospital Affiliated to Wenzhou Medical University and randomly divided into the control group and the observation group according to the digital table, with 130 cases in each group.Both two groups were given routine therapy.The control group was treated with lorazepam tablets.Based on the control group, the observation group was given Linglianhua granule (1 bag/time and bid). The two groups were treated for 8 weeks.The scores of Hamilton's depression scale(HAMD)-17, self-rating depression scale (SDS), clinical efficacy, and serum levels of IL-8, IL-17, NE, 5-HT were compared between the two groups.
Results:After treatment for 8 weeks, the HAMD, SDS score of the observation group were obviously lower than those of the control group(t=7.903, 12.331, all P=0.00). The total effective rate of the observation group(93.85%) was higher than that of the control group(84.62%)(χ2=4.843, P<0.05). After treatment for 8 weeks, the serum levels of IL-8 and IL-17 in the observation group were lower, while the NE and 5-HT levels were higher, compared with those in the control group(t=9.403, 14.439, 19.431, 28.931, all P=0.00).
Conclusion:Based on the routine therapy, Linglianhua granule in treating depression after coronary heart disease with syndrome of heart-kidney imbalance can promote improvement of depression symptoms, increase the efficacy.Inhibiting serum levels of IL-8, IL-17 and up-regulation of NE and 5-HT may be related with the efficacy.
