Correlation analysis of antibody titer and immune balance after infection of mycoplasma pneumoniae in children with bronchial asthma
10.3760/cma.j.issn.1008-6706.2019.19.018
- VernacularTitle: 支气管哮喘患儿感染肺炎支原体后抗体滴度与免疫平衡的相关性分析
- Author:
Linghui LUO
1
Author Information
1. Department of Paediatrics, Maternal and Child Health Care Hospital of Qihe County, Shandong 251100, China
- Publication Type:Journal Article
- Keywords:
Bronchi;
Asthma;
Mycoplasma pulmonis;
Immunity
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(19):2386-2388
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the correlation of antibody titer and immune balance after infection of mycoplasma pneumoniae in children with bronchial asthma.
Methods:From October 2010 to August 2015, 108 children with bronchial asthma infected with mycoplasma pneumoniae were selected.There were 71 patients in the observation group, children with mycoplasma pneumoniae antibody titers >1∶160, and 37 cases were selected as control group, mycoplasma pneumonia antibody titer≤1∶160.The titer of mycoplasma antibody, serum interferon gamma(IFN-γ), interleukin-4(IL-4) and interleukin-17(IL-17) were measured.
Results:The serum IFN-γ, IL-4 and IL-17 levels in the control group were (41.04±3.13)μg/L, (17.04±3.16)μg/L and (30.81±4.23)μg/L, respectively, which in the observation group were (33.26±3.17)μg/L, (24.15±5.09)μg/L and (41.29±5.09)μg/L, respectively.The serum IL-4 and IL-17 levels of the observation group were significantly higher than those of the control group(t=5.126, 3.429, all P<0.05). After infection of mycoplasma pneumoniae, the serum IFN-γ in the observation group decreased significantly(t=4.168, P<0.05).
Conclusion:The titer of antibody after mycoplasma pneumoniae infection in children with bronchial asthma is closely related to the immune balance.The higher the antibody titer, the more serious the immune imbalance.
