Research advances of interleukin-17 in pathogenesis of non-alcoholic fatty liver diseases
10.3760/cma.j.issn.2095-428X.2019.19.018
- VernacularTitle: 白细胞介素-17在非酒精性脂肪性肝病发病机制中的研究进展
- Author:
Fuli ZHU
1
;
Qingwen SHAN
Author Information
1. Department of Pediatrics, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
- Publication Type:Review
- Keywords:
Non-alcoholic fatty liver disease;
Interleukin-17;
Insulin resistance;
Oxidative stress
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(19):1508-1511
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, with the development of economy, the improvement of people′s living standards, the change of lifestyle and the prevalence of obesity and diabetes, the incidence rate of non-alcoholic fatty liver disease(NAFLD) in the world is increasing year by year.NAFLD is a sort of liver disease spectrum associated with genetics-environment-metabolic stress and is a common multifactorial involvement of liver disease.Interleukin(IL)-17 is a pro-inflammatory factor mainly produced by T helper cell 17.Recently, it has been found that the expression of IL-17 is increased in various liver diseases, and relevant studies have confirmed that IL-17 can facilitate the occurrence and development of NAFLD, and the underlying mechanisms are related to insulin resistance, oxidative stress, lipid peroxidation, gut microbiota dysbiosis, immune inflammation and lipoapoptosis, etc.Now, the research advances of IL-17 in the pathogenesis of NAFLD are reviewed.
