Analysis of antibiotic resistance and influencing factors for Helicobacter pylori in children
10.3760/cma.j.issn.2095-428X.2019.19.004
- VernacularTitle: 儿童幽门螺杆菌耐药情况及影响因素分析
- Author:
Dongdan LI
1
;
Dexiu GUAN
1
;
Jing GUO
1
;
Yongli FANG
1
;
Shu GUO
1
;
Lihua HE
2
;
Jianzhong ZHANG
2
;
Liya ZHOU
3
;
Feihong YU
1
;
Jin ZHOU
1
;
Guoli WANG
1
;
Jing ZHANG
1
;
Xiwei XU
1
Author Information
1. Department of Gastroenterology, Beijing Children′s Hospital of Capital Medical University, Children′s National Medical Center, Beijing 100045, China
2. State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China
3. Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Antibiotic resistance;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(19):1450-1453
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the antibiotic resistance of Helicobacter pylori(Hp) isolates cultured from endoscopic gastric mucosal samples and influencing factors for antibiotic resistance in children.
Methods:From April 2013 to February 2016, Hp cultured from mucosa samples of the gastric antrum and the body of stomach was investigated in 246 patients with 13C breath test positive examined by gastroscopy.Resistance to Amoxicillin, Clarithromycin, Metronidazole, Tetracycline was tested for Hp by using E-test.The clinical data were collected from the patients, and the relationship among age, gender, endoscopic diagnosis, histological performance, eradication number factors and antibiotic resistance rate were analyzed.
Results:Of 246 specimens, 174 cases (70.7%) were positive.The overall antibiotic resistance rates of isolates obtained were 96.55% (168/174 cases), 57.47% (100/174 cases), 4.02% (7/174 cases), 1.15%(2/174 cases) with respect to Clarithromycin, Metronidazole, Tetracycline and Amoxicillin.An antibiotic resistance rate was 43.10% (75/174 strains), among which the Clarithromycin resistance rate was 93.33% (70/75 strains), and the Metronidazole resistance rate was 6.67% (5/75 strains). Double resistance rate was of 54.02%(94/174 strains), among which the resistances rate of Clarithromycin+ Metronidazole was 52.30%(91/94 strains), and the resistances rate of Clarithromycin+ Tetracycline was 1.72%(3/94 strains). Triple resistance rate of Clarithromycin+ Metronidazole+ Tetracycline was 1.15%(2/174 strains). Quadruple resistance rate of Clarithromycin+ Metronidazole+ Amoxicillin+ Tetracycline was 1.15%(2/174 strains). Factor analysis showed that the resistance rate of Clarithromycin in children who had failed in eradication therapy [98.7%(148/150 cases)] was higher than that in children who had not undergone eradication therapy [83.3%(20/24 cases)], and the difference was statistically significant(χ2=14.610, P<0.05). There was no significant difference in the relationship between Hp resistance to Metronidazole and Clarithromycin and the age, gender, endoscopic diagnosis and histological manifestations(all P>0.05).
Conclusions:Hp resistance rate to Clarithromycin, Metronidazole is very high in children, but it is relatively low to Amoxicillin and Tetracycline, and multiple antibiotic resistance is at high prevalence.
