Relationship between sleep disorders, pain and C-reactive protein in patients with rheumatoid arthritis
10.3760/cma.j.issn.1672-7088.2019.18.005
- VernacularTitle: 类风湿关节炎患者不适症状与C反应蛋白关系的研究
- Author:
Lijun LIANG
1
;
Zhonghua GUO
;
Jing SHI
Author Information
1. Department of Rheumatology and Immunology, Dalian Central Hospital, Dalian 116003, China
- Publication Type:Clinical Trail
- Keywords:
Arthritis;
Rheumatoid diseases;
C-reactive protein
- From:
Chinese Journal of Practical Nursing
2019;35(18):1381-1383
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between sleep disorders, pain and C-reactive protein in patients with rheumatoid arthritis.
Methods:A total of 115 patients with rheumatoid arthritis admitted to the Department of Rheumatology and Immunology of the hospital from March 2014 to March 2016 were selected by convenient sampling. The demographics of each patient were recorded. Each selected patient was assessed for sleep disorder by the Sleep Disorders Questionnaire (SDQ). Pain assessment was performed for each patient using a simplified McGill pain score. At the time of admission, our department nurses was responsible for blood collection and C-reactive protein (CRP), and >10 mg/L was positive for CRP. The 37 questions of sleep disorders were stratified, and each stratification variable was correlated with pain scores. Each patient demographic variable, sleep disorder questionnaire score, pain score, and CRP adjusted for CRP were used to correct the disordered multi-class Logistic regression analysis.
Results:All patients had a sleep score of 21.2±10.3 and a pain score of 5.4±3.6. There were 9 items in the sleep disorder that were statistically significantly associated with pain scores, including apnea, sleep hypopnea, difficulty falling asleep, limb convulsions during sleep, limb numbness during sleep, nightmares during sleep, wakefulness during sleep, snoring during sleep Pain was significantly positively correlated (r = 0.22-0.57, P < 0.01). Diabetes, hypertension, sleep disturbance, and pain in the regression analysis were independent factors of CRP (β=0.21-0.33, P<0.05).
Conclusions:Sleep disorders and pain in patients with rheumatoid arthritis can increase CRP and aggravate the disease. The care process requires special attention to patients with sleep disorders and pain.
