Effect of escitalopram in the treatment of alcohol－dependent patients with depression
10.3760/cma.j.issn.1008-6706.2019.18.010
- VernacularTitle: 艾司西酞普兰治疗伴抑郁酒精依赖患者的效果观察
- Author:
Haiping YU
1
;
Suilin JIA
;
Wei ZHANG
;
Yalin CHEN
Author Information
1. Department of Psychiatry, the Seventh People′s Hospital of Wenzhou, Wenzhou, Zhejiang 325000, China
- Publication Type:Journal Article
- Keywords:
Alcoholic beverages;
Substance-related disorders;
Dependent personality disorder;
Depression;
Escitalopram;
Placebos;
Quality of life;
Social participation
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(18):2220-2223
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical effect of escitalopram in the treatment of alcohol-dependent patients with depressive symptoms and its influence on social function recovery.
Methods:From January 2016 to December 2017, 80 alcohol-dependent patients with depressive symptoms in the Seventh People's Hospital of Wenzhou were selected and divided into two groups by random digital table method, with 40 cases in each group.The observation group was treated with escitalopram.The control group was treated with placebo for 2 months.The scores of depression, social dysfunction screening scale, quality of life and incidence of adverse reactions were compared between the two groups.
Results:After treatment for 1 month and 2 months, the depression scores of the observation group were (15.02±2.23)points and (9.02±2.12)points, respectively, which were lower than those of the control group[(20.13±2.12)points, (15.24±2.15)points](t=10.504, 13.029, all P<0.05). After treatment for 1 month and 2 months, the scores of the screening scale for social functional defects in the observation group were (2.85±1.23)points and (0.89±0.52)points, respectively, which were lower than those in the control group[(4.13±1.62)points, (2.52±1.16)points](t=3.930, 8.110, all P<0.05). The scores of physical health, mental health, physical life, social function and total quality of life in the observation group were (87.47±5.69)points, (84.63±5.21)points, (87.16±5.24)points, (85.46±5.95)points and (86.12±5.95)points, respectively, which were higher than those of the control group[(79.58±5.93)points, (76.72±7.82)points, (79.28±5.57)points, (75.92±5.45)points, (78.46±5.85)points](t=5.995, 5.257, 6.435, 7.384, 5.733, all P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).
Conclusion:Escitalopram in the treatment of alcohol-dependent patients with depressive symptoms has good effect, not only helps to improve the depression, but also helps to promote the recovery of social function of the patients, and the safety is relatively high.
