Clinical value of ranibizumab combined with fundus laser in the treatment of macular edema secondary to branch retinal vein occlusion
10.3760/cma.j.issn.1008-6706.2019.17.016
- VernacularTitle: 雷珠单抗联合眼底激光治疗视网膜分支静脉阻塞继发黄斑水肿的价值研究
- Author:
Xiaoyan ZHENG
1
;
Xiaoxia PAN
;
Cui JIN
Author Information
1. Department of Ophthalmology, the People's Hospital of Linfen, Linfen, Shanxi 041000, China
- Publication Type:Journal Article
- Keywords:
Retinal vein occlusion;
Macular edema;
Retinal vessels;
Fundus oculi;
Laser therapy;
Comparative effectiveness research;
Rezumab
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(17):2114-2118
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical value of ranibizumab combined with fundus laser in the treatment of macular edema secondary to branch retinal vein occlusion(RVO).
Methods:From June 2016 to June 2017, 98 patients with RVO secondary macular edema in the People's Hospital of Linfen were randomly divided into three groups according to the digital table: A group (30 cases) treated with simple fundus laser, B group (33 cases) treated with intravitreal injection of ranibizumab, C group(35 cases) treated with fundus laser combined with intravitreal injection of ranibizumab.The best corrected visual acuity(BCVA), macular fovea thickness(CMT), leakage rate, injection times and complications were compared among the three groups before and after treatment.
Results:At 3, 6, 9, 12 months after treatment, the BCVA among A group, B group and C group had statistically significant differences (F=4.165, 5.021, 6.954, all P<0.05), and the BCVA of C group was better than that of B group, the BCVA of B group was better than that of A group (t=3.985, 3.852, 3.779, 4.021, 3.624, 3.729, all P<0.05). There were statistically significant differences in CMT among A group, B group and C group at 3 months and 6 months after treatment (F=6.772, 14.025, all P<0.05), and the CMT of C group was less than that of B group, the CMT of B group was less than that of A group (t=5.325, 11.251, 3.992, 6.895, all P<0.05). At 6 months after treatment, the leakage rate in C group (2.86%) was lower than that in B group (18.18%), the leakage rate in B group was lower than that in A group (23.33%) (χ2=6.148, P<0.05). The injection times of ranibizumab in B group was (2.93±1.52), which was significantly less than that in C group (2.00±0.56)(t=3.349, P<0.05).
Conclusion:The short-term clinical effect of ranibizumab combined with fundus laser in the treatment of macular edema secondary to RVO is better than laser therapy and ranibizumab alone, and the injection times of ranibizumab can be reduced.
