Comparison of the effects of aspirin and clopidogrel on coronary heart disease
10.3760/cma.j.issn.1008-6706.2019.16.002
- VernacularTitle: 阿司匹林与氯吡格雷对冠心病的治疗效果比较
- Author:
Jianlong ZHANG
1
;
Wentao JIANG
Author Information
1. Department of Internal Medicine, the Third People's Hospital of Yuyao, Yuyao, Zhejiang 315400, China
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Adverse events;
Cardiac function;
Platelet aggregation rate;
Prothrombin activity;
Thrombin activation time;
Aspirin;
Clopidogrel
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(16):1925-1928
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the therapeutic effect of aspirin and clopidogrel on coronary heart disease.
Methods:From June 2016 to July 2017, 186 patients with coronary heart disease in the Third People's Hospital of Yuyao were divided into control group and observation group according to different treatment methods, with 93 cases in each group.Both two groups were treated with routine symptomatic therapy, the control group was given aspirin and the observation group was given clopidogrel.Biochemical indicators, cardiac function and adverse events were observed.
Results:There were no statistically significant differences between the two groups before treatment(all P>0.05). The platelet aggregation rate and activation time of partial thrombin of the observation group were (38.11±2.15)% and (48.21±3.50)s, respectively, which were better than those of the control group(t=48.819, 18.752, all P<0.05). There were no statistically significant differences in prothrombin activity and prothrombin time between the two groups(all P>0.05). The probability of grade Ⅳ and grade Ⅰ in the observation group was 8.60% and 38.71%, respectively, which was significantly different from those in the control group(χ2=5.243, 6.541, all P<0.05). The incidence rate of adverse events in the observation group(1.08%) was lower than that in the control group(7.53%), and the difference was statistically significant(χ2=4.072, P<0.05).
Conclusion:Clopidogrel is more effective than aspirin in the treatment of coronary heart disease.It can significantly improve the coagulation function, cardiac function, and it is safe and with less adverse reactions.
