Research progress of autoimmune lymphoproliferative syndrome
10.3760/cma.j.issn.2095-428X.2019.16.020
- VernacularTitle: 自身免疫淋巴增生综合征研究进展
- Author:
Tingting YU
1
;
Xiaodong ZHAO
;
Huawei MAO
Author Information
1. Department of Rheumatology and Immunology, Children′s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014, China
- Publication Type:Review
- Keywords:
Autoimmune lymphoproliferative syndrome;
Pathogenesis;
Progress
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(16):1269-1273
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in an accumulation of lymphocytes and childhood onset chronic lymphadenopathy, splenomegaly, multilineage cytopenias, and an increased risk of B-cell lymphoma.Since then, with more than 500 patients with ALPS diagnosed worldwide.In this paper, it is hoped that harmonizing the diagnosis and classification of ALPS will foster be-tter understanding of the pathogenesis of ALPS.
