Recovery time and risk factors of childhood coagulopathy caused by rodenticide poisoning
10.3760/cma.j.issn.2095-428X.2019.16.012
- VernacularTitle: 儿童鼠药中毒致凝血功能障碍恢复时间及相关因素研究
- Author:
Ying LI
1
;
Yongchun SU
1
;
Ying XIAN
1
;
Jianwen XIAO
1
;
Xianhao WEN
1
;
Xianmin GUAN
1
;
Yuxia GUO
1
;
Yali SHEN
1
;
Yan MENG
1
;
Jia TANG
2
;
Weijun ZHOU
2
;
Jie YU
1
Author Information
1. Department of Hemooncology, Children′s Hospital, Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China
2. Department of Pediatrics, the People′s Hospital of Yubei District of Chongqing, Chongqing 401120, China
- Publication Type:Journal Article
- Keywords:
Anticoagulant rodenticide;
Coagulopathy;
Treatment;
Prognosis
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(16):1241-1243
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the recovery time and risk factors of coagulopathy caused by rodenticide poisoning through analyzing and following up the confirmed cases, and to provide more useful guidance information for the clinic practice.
Methods:A total of 96 cases with coagulation dysfunction caused by anticoagulant rodenticide poiso-ning in Children′s Hospital, Chongqing Medical University from January 2014 to December 2016, were analyzed retrospectively.The recovery time of coagulation function and the relationship between recovery time and drug involved way, dysfunction organs and poison concentration were studied respectively.
Results:(1) A total of 96 patients were hospitalized because of severe coagulopathy caused by the poisoning of second generation anticoagulant rodenticide.Brodifacoum was detected from 33 blood samples and the median concentration was 364 μg/L (55-4 654 μg/L). Bromadiolone was detected from 7 blood samples and the median concentration was 130 μg/L (18-652 μg/L). Brodifacoum and Bromadiolone were both detected from 8 cases and the median concentration was 741 μg/L (63-6 000 μg/L) and 11 μg/L (3-3 694 μg/L), respectively.(2) A total of 57 cases of the patients were successfully followed up.A total of 18 cases were confirmed with oral poisoning, 16 cases with dermal poisoning, while 23 cases denied any involved ways of poisoning, and 7 cases had organs dysfunction.The follow-up time was 12-54 months.All the hospitalized patients were given specific antidote Vitamin K treatment and recovered successfully without any sequelae.(3) The median recovery time of coagulopathy caused by rodenticide poisoning was 2.5 months.(4) The recovery time of coagulation function was positively correlated with the plasma concentration of Brodifacoum(r=0.619, P<0.01). (5) There was no significant correlation between recovery time and organ dysfunction or drug involved ways of poisoning involvement (all P>0.05).
Conclusions:The recovery time of coagulation dysfunction caused by anticoagulant rodenticide in children is much longer.The higher the concentration of Brodifacoum poison is, the longer the recovery time.Enough supplementation course of Vitamin K should be given according to the follow-up of coagulation function.
