Therapeutic effect of injectable mouse nerve growth factor combined with rehabilitation training on cerebral palsy in children
10.3760/cma.j.issn.2095-428X.2019.16.011
- VernacularTitle: 注射用鼠神经生长因子联合康复训练治疗脑性瘫痪患儿的临床疗效
- Author:
Huiling ZHAO
1
;
Huanhuan FENG
2
;
Xiaojie LI
1
;
Wei PANG
2
Author Information
1. Department of Pediatric Cerebral Palsy Rehabilitation, the Third Affiliated Hospital of Jiamusi University, Jiamusi 154002, Heilongjiang Province, China
2. Department of Pediatric Neurology, the Third Affiliated Hospital of Jiamusi University, Jiamusi 154002, Heilongjiang Province, China
- Publication Type:Journal Article
- Keywords:
Cerebral palsy;
Rehabilitation training;
Nerve growth factor;
Repair of nerve injury
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(16):1237-1240
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the therapeutic effect of mouse nerve growth factor (mNGF) combined with conventional rehabilitation training on children with cerebral palsy (CP).
Methods:According to the inclusion criteria, 60 children with CP(spastic diplegia) who were treated at the Third Affiliated Hospital of Jiamusi University were selected by double-blind method from June to December in 2016.Sixty children with CP were stratified according to age, gender and Gross Motor Function Classification System (GMFCS) (the subjects were classified into 2 age groups: 0-2 years old and 2-4 years old), and then they were randomly divided by draw method: the control group received routine rehabilitation; the experimental group received mNGF additionally.The children with CP in the experimental group were treated with 18 μg mNGF every day for 10 days and then discontinued for 5 days, with 20 injections per month for 1 course, a total of 3 courses.After 3 courses of treatment, the changes in Gesell Development Diagnosis Schedules (GDDS), Peabody Developmental Motor Scales-Gross Motor (PDMS-GM), Peabody Developmental Motor Scales-Fine Motor (PDMS-FM) and Range of Motion (ROM) of the lower extremity were compared between the 2 groups.
Results:After 3 months of treatment, the changes of Gesell(gross motor: 57.40±18.13, 44.87±10.95; fine motor: 64.83±18.04, 62.60±17.34; adaptability: 76.07±14.99, 70.57±11.19; language: 74.20±15.07, 71.23±13.38, personal-social interaction: 67.40±14.10, 61.40±12.96), PDMS-GM(94.33±16.03, 81.13±20.15), PDMS-FM scores(91.53±19.73, 91.10±15.84) and ROM[adductors angle: left (69.67±22.2)°, (49.17±21.82)°; right (69.83±21.63)°, (49.67±21.61)°; popliteal angle: left (160.08±30.02)°, (125.50±25.78)°; right (160.17±22.46)°, (126.00±25.31)°; dorsal flexion angle of foot: left (10.17±6.09)°, (4.33±7.28)°; right (9.83±6.23)°, (4.83±7.48)°] in the experimental group and the control group were all significantly higher than those before treatment, and the differences were statistically significant (all P<0.05). After 3 months of treatment, the Gesell gross motor(57.40±18.13) and PDSM-GM scores(94.33±16.03) in the experimental group were significantly higher than those (44.87±10.95, 81.13±20.15, respectively) in the control group, and the differences were statistically significant (all P<0.05).
Conclusions:Conventional rehabilitation therapy combined with mNGF has more significant effect on the development and motor function of children with CP than routine rehabilitation training.
