Association of STAT3 gene polymorphism with susceptibility to asthma in children
10.3760/cma.j.issn.2095-428X.2019.16.005
- VernacularTitle: STAT3基因多态性与儿童支气管哮喘易感性的相关性
- Author:
Fangfang ZHONG
1
,
2
,
3
;
Danwei REN
3
,
4
;
You YANG
1
,
2
,
3
;
Chunyan LIU
3
,
4
;
Yan ZOU
3
,
4
;
Wenjun LIU
1
,
2
,
3
Author Information
1. Faculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
2. First Department of Pediatrics, Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
3. Birth Defects Clinical Medical Research Center of Sichuan Province, Luzhou 646000, Sichuan Province, China
4. First Department of Pediatrics, Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
- Publication Type:Journal Article
- Keywords:
STAT3 gene;
Single nucleotide polymorphism;
Asthma;
Susceptibility;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(16):1215-1218
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between STAT3 gene (rs2293152, rs957970) polymorphism and susceptibility to bronchial asthma in children, and to lay the foundation for search of the candidate pathogenic gene of asthma and early prevention of the disease.
Methods:One hundred and thirty hospitalized asthmatic children or out-patients with asthma at Affiliated Hospital of Southwest Medical University from September 2013 to September 2017 were selected as asthmatic group, and at the same time 145 healthy children were selected from the Affiliated Hospital of Southwest Medical University as the healthy control group.Apply sequence specific primers-polymerase chain reaction (SSP-PCR) was applied to detect susceptibility single nucleotide polymorphism (SNP) of STAT3 gene (rs2293152, rs9579700). The statistical differences in distribution between genotype and allele were analyzed between the asthma group and the healthy control group.
Results:The distribution frequency of CC genotype of rs2293152 in STAT3 gene was significantly higher in the asthmatic group (19.2%)than that in the healthy control group (9.0%) (χ2=6.065, P=0.014). C allele was significantly higher in asthmatic group (41.9% vs.33.8%) (χ2=3.861, P=0.049). There was no significant difference in the distribution of rs957970 in STAT3 gene between the asthma group and the healthy control group.
Conclusions:The SNP of rs2293152 in STAT3 gene is associated with susceptibility to asthma in children in South Sichuan.C allele may be the susceptible gene for childhood asthma, while the SNP of rs957970 in STAT3 gene has no significant correlation with childhood asthma in Southern Sichuan.
