Clinical effect of fasudil combined with cattle encephalon glycoside and ignotin injection in the treatment of diabetic deafness and tinnitus
10.3760/cma.j.issn.1008-6706.2019.15.002
- VernacularTitle: 法舒地尔联合脑苷肌肽治疗2型糖尿病并耳鸣耳聋的效果分析
- Author:
Huiqing WANG
1
;
Guiying WANG
1
;
Yinyu LI
1
;
Jimin ZHANG
1
;
Ping GUO
1
;
Jinhua ZHANG
1
;
Jiezhong WEI
2
Author Information
1. Department of Endocrinology, the Fifth People's Hospital of Datong, Datong, Shanxi 037004, China
2. Institute of Brain Science, Shanxi Datong University, Datong, Shanxi 037004, China
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Tinnitus;
Deafness;
Hearing;
Fasudil;
Cerebral glycoside;
Comparative effectiveness research
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(15):1798-1801
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical effect of fasudil plus cattle encephalon glycoside and ignotin injection in treating diabetic deafness and tinnitus.
Methods:From January 2016 to December 2016, 60 patients with diabetic deafness and tinnitus in the Fifth People's Hospital of Datong were selected and randomly divided into two groups according to the digital table, with 30 cases in each group.The treatment group received fasudil injection plus cattle encephalon glycoside and ignotin injection (iv gtt), and the control group received cattle encephalon glycoside and ignotin injection.The effective rate after treatment for 10 days and 20 days were compared between the two groups.
Results:Compared with the control group, the effective rate of hearing in the treatment group was not higher at 10 days after treatment (26.7% vs.16.7%, χ2=0.884, P=0.347), while it was higher in the treatment group at 20 days after treatment (53.3% vs.26.7%, χ2=4.444, P=0.035). The effective rate of tinnitus in the treatment group at 10 days after treatment was not higher compared with the control group (30.0% vs.20.0%, χ2=1.491, P=0.222), while it was higher in the treatment group at 20 days after treatment (56.7% vs.30.0%, χ2=4.344, P=0.037). As far as hearing threshold: there were no statistically significant differences between the control group and the observation group before treatment and 10 days after treatment(all P>0.05). The hearing threshold of the observation group was significantly better than that of the control group at 20 days after treatment (t=-2.511, P=0.02).
Conclusion:The combination therapy of fasudil injection plus cattle encephalon glycoside and ignotin injection has better efficacy for diabetic deafness and tinnitus.
