Progress in the application of oncolytic virus in the treatment of hematological malignancies
10.3760/cma.j.issn.2095-428X.2019.15.002
- VernacularTitle: 溶瘤病毒在血液系统恶性肿瘤治疗中的研究进展
- Author:
Zhixu HE
1
,
2
;
Xing ZHAO
3
,
4
Author Information
1. Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
2. Key Laboratory of Adult Stem Cell Transformation Research, Chinese Academy of Medical Sciences/Stem Cell and Tissue Engineering Research Center, Guizhou Medical University, Guiyang 550004, China
3. Key Laboratory of Adult Stem Cell Transformation Research, Chinese Academy of Medical Sciences/Stem Cell and Tissue Engineering Research Center, Guizhou Medical University, Guiyang 550004, China
4. Department of Immunology, Guizhou Medical University, Guiyang 550025, China
- Publication Type:Journal Article
- Keywords:
Hematological malignancies;
Oncolytic virus;
Immunotherapy
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(15):1127-1131
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the incidence of hematological malignancies has increased year by year, although with the progress of chemotherapy, targeted therapy and hematopoietic stem cell transplantation, the efficacy of some types of lymphoma and leukemia has been greatly improved.However, the prognosis is still poor and the fatality rate is high.Finding new strategies to improve the curative effect has become an urgent problem to be solved.Oncolytic virus can promote anti-tumor response by selectively destroying tumor cells and inducing specific anti-tumor immune response.At present, oncolytic virus has become an effective strategy for the treatment of a variety of malignant tumors.A lot of breakthrough progress has also been made in the treatment of hematological malignant tumors.In this paper, the latest research progress of oncolytic virus in the treatment of hematological malignant tumors in recent years is reviewed.
