The correlation between chorioamnionitis-induced abnormal placental microvessel and platelet metabolism of preterm infants
10.3760/cma.j.issn.2095-428X.2019.14.003
- VernacularTitle: 绒毛膜羊膜炎致胎盘微血管异常与早产儿血小板代谢的相关性
- Author:
Yunbei RAO
1
;
Xiaoling ZHANG
1
;
Zhicheng ZHONG
2
;
Jiangyu ZHANG
3
;
Zhuxiao REN
1
;
Jiayu MIAO
1
;
Shumei YANG
1
;
Jie YANG
1
Author Information
1. Department of Neonatology, Guangdong Women and Children Hospital, Guangzhou 511400, China
2. Prenatal Diagnosis Center, Guangdong Women and Children Hospital, Guangzhou 511400, China
3. Department of Pathology, Guangdong Women and Children Hospital, Guangzhou 511400, China
- Publication Type:Journal Article
- Keywords:
Chorioamnionitis;
Platelet;
Platelet activation;
Placenta;
Infant, premature
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(14):1048-1052
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of chorioamnionitis on placental microvessel and platelet metabolism in premature and the correlation between them.
Methods:With clinical randomized controlled trial (RCT), the cases were matched by 11 according to gestational ages and divided into 2 groups according to the placental pathology results: chorioamnionitis group and control group, 32 cases in each group.Dates were obtained for preterm infants (gestational age<37 weeks) admitted to the Department of Neonatology at Guangdong Women and Children Hospital, born between June and December 2016.The platelet parameter [platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT)], birth weight, thrombocytopenia, hemorrhage complication, miscrovascular density (MVD) in placenta, platelet activating factors (CD62p, CD63) and thrombopoietin (TPO) in preterm infants were recorded and compared.
Results:In chorioamnionitis group, the infant birth weight[(1.90±0.41) kg vs.(2.31±0.62) kg] and the PLT in 72 hours [<24 h (197.97±63.43)×109/L vs.(266.34±69.92)×109/L; 24-72 h (202.28±29.70)×109/L vs.(256.38±69.96)×109/L] were significantly lower compared with the control group, and the differences were statistically significant(all P<0.05). The incidence of early thrombocytopenia(37.50% vs.9.38%), intracranial hemorrhage(40.62% vs.15.63%), MPV [(8.73±0.89) fL vs.(8.27±0.64) fL] and PDW[(59.46±5.90)% vs.(55.20±5.37)%] in 24 hours were significantly higher in chorioamnionitis group, and the differences were statistically significant (all P<0.05). The placental MVD in chorioamnionitis group significantly decreased[(9.08±1.35)% vs.(12.89±1.36)%, P<0.05 ]. The level of CD62p, CD63 and TPO in umbilical cord blood were significantly higher in chorioamnionitis group[(25.37±5.20)% vs.(10.35±2.94)%, (9.49±1.58)% vs.(4.04±1.21)%, (271.08±197.22) μg/L vs.(141.87±78.10) μg/L, all P<0.05]. The placental MVD was positively associated with PLT (r=0.74, P<0.05) and negatively associated with CD62p, CD63 and TPO among infants with chorioamnionitis (r=-0.64, -0.44, -0.44, all P<0.05).
Conclusions:The chorioamnionitis may decrease the MVD in placenta and activate platelet in fetal circulation, damaged placental microvessel may activate platelet further.
