Comparison of ganciclovir combined with dexamethasone and ganciclovir alone in the treatment of acute idiopathic facial neuritis
10.3760/cma.j.issn.1008-6706.2019.13.010
- VernacularTitle: 更昔洛韦联合地塞米松与单用更昔洛韦治疗急性特发性面神经炎的疗效比较
- Author:
Qing LU
1
;
Xudong PAN
2
;
Bingxu WANG
3
Author Information
1. Medical College, Qingdao University, Qingdao, Shandong 266001, China
2. Department of Neurology, The Affiliated Hospital of Medical College of Qingdao University, Qingdao, Shandong 266001, China
3. Department of Neurology, Peking University Medical Center Hospital Luzhong Hospital, Zibo, Shandong 255400, China
- Publication Type:Journal Article
- Keywords:
Bell palsy;
Ganciclovir;
Dexamethasone;
Vitamin B12
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(13):1574-1577
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the clinical effects of ganciclovir combined with dexamethasone and ganciclovir alone in the treatment of acute idiopathic facial neuritis.
Methods:From March 2014 to March 2016, 80 patients with acute idiopathic facial neuritis admitted in the department of neurology of Luzhong Hospital were randomly divided into treatment group and control group according to the admission sequence, with 40 cases in each group.The two groups were given basic treatment (mecobalamine intramuscular injection + clonazepam and continuous application for 15d), and the treatment group was excluded from the corticosteroid application.On this basis, ganciclovir combined with dexamethasone was applied in the treatment group, and ganciclovir was applied in the control group.Both two groups had a course of 15 days.All the patients were graded by Portmann simple scale before treatment and at 7 days and 15 days after treatment, and statistical significance of SPSS13.0 software was adopted.
Results:Intra-group comparison: after treatment of 7d, the score of the treatment group was (10.11±3.62)points, which was significantly higher than (2.60±2.22)points before treatment(t=1.432, P<0.05). The score had no statistically significant difference between 7d after treatment[(10.11±3.62)points] and 15d after treatment[(11.82±3.02)points] in the treatment group (t=1.582, P>0.05). In the control group, the score had no statistically significant difference between 7d after treatment[(3.22±3.12)points] and before treatment[(2.70±2.30)points] (t=0.923, P>0.05). Comparison between the two groups: there was no statistically significant difference in pre-treatment score between the two groups (P>0.05). The score of the treatment group at 7d after treatment[(10.11±3.62)points] was significantly different from that of the control group[(3.22±3.12)points](t=1.633, P<0.05). There was no statistically significant difference in scores between the two groups at 15d after treatment (P>0.05).
Conclusion:Ganciclovir combined with dexamethasone and ganciclovir alone are effective in the treatment of acute idiopathic facial neuritis.Although the improvement effect of the combined treatment is earlier than that of single use, there is no significant difference in the total effective rate between the two treatments.
