Clinical study of cystatin C in assessing the severity of community acquired pneumonia
10.3760/cma.j.issn.1008-6706.2019.13.008
- VernacularTitle: 胱抑素C评估社区获得性肺炎严重程度的临床研究
- Author:
Tao BIAN
1
;
Mingqi TAN
Author Information
1. Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, China
- Publication Type:Journal Article
- Keywords:
Cystatin c;
Community-acquired infections;
Procalcitonin;
C-reactive protein;
D-dimer;
Fibrinogen;
Leukocyte count;
Neutrophils;
Pneumonia;
Severity of illness index
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(13):1566-1569
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of cystatin C in predicting the severity of community-acquired pneumonia(CAP).
Methods:From January 2016 to August 2016, the clinical data of 122 patients with CAP in Shengjing Hospital of China Medical University were retrospectively analyzed.The patients were divided into low-risk group(74 cases) and middle-high risk group(48 cases) according to pneumonia severity index (PSI). The cystatin C, procalcitonin, C-reactive protein(CRP), white blood cell (WBC) count, neutrophil percentage(NE%), D-dimer and fibrinogen(FIB) levels in hospitalized patients were detected.The relationship between cystatin C and the above related indicators and the PSI was evaluated.Draw ROC curve with cystatin C and above indicators to predict severity of CAP.
Results:In the low-risk group, the levels of procalcitonin, CRP, WBC count, NE%, D-dimer, FIB were[0.08(0.04, 0.23)]ng/L, [42.35(12.52, 93.70)]mg/L, [7.85(6.23, 10.38)]×109/L, (66.87±13.49)%, [215.00(134.25, 410.25)]μg/L, [4.52(3.71, 5.14)]g/L, respectively, which in the middle and high risk group were [0.25(0.07, 0.54)]ng/L, [74.30(40.45, 122.75)]mg/L, [7.90(5.78, 10.63)]×109/L, (73.97±10.77)%, [417.50(239.75, 730.00)]μg/L, [4.57(3.87, 5.08)]g/L, respectively, the differences of NE%, procalcitonin, CRP, D-dimer between the two groups were statistically significant(t=3.064, U=3.024, 2.800, 3.771, all P<0.05), the WBC count, FIB had no statistically significant differences between the two groups (all P>0.05). In the low-risk group, the level of cystatin C was[0.82(0.68, 0.91)]mmol/L, which in the middle-high risk group was[1.32(1.12, 1.54)]mmol/L, the difference between the two groups was statistically significant(U=7.978, P<0.001). When the level of cystatin C was 0.975 mmol/L, the sensitivity for the diagnosis of pneumonia severity was 95.8%, with a specificity of 85.1%.
Conclusion:Monitoring cystatin C levels can be used as an indicator of inflammatory response and can predict the severity of pneumonia.
