Clinical and imaging features of 13 children with myelin oligodendrocyte glycoprotein antibody encephalomyelitis
10.3760/cma.j.issn.2095-428X.2019.13.008
- VernacularTitle: 儿童髓鞘少突胶质细胞糖蛋白抗体脑脊髓炎13例临床与影像学特征
- Author:
Min XU
1
;
Hu GUO
;
Yan HE
;
Li WANG
;
Chao LIANG
;
Le DING
;
Guo ZHENG
;
Xiaopeng LU
;
Gang ZHANG
Author Information
1. Department of Neurology, Children′s Hospital of Nanjing Medical University, Nanjing 210008, China
- Publication Type:Journal Article
- Keywords:
Child;
Myelin oligodendrocyte glycoprotein antibody;
Encephalomyelitis;
Clinical and imaging features
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(13):997-1001
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical and imaging features of myelin oligodendrocyte glycoprotein antibody(MOG) encephalomyelitis in children.
Methods:The clinical, laboratory finding, imaging and follow-up data of 13 children with MOG encephalomyelitis (MOG-EM) diagnosed by Children′s Hospital of Nanjing Medical University from December 2016 to December 2018 were retrospectively analyzed.
Results:Among the 13 children, 4 cases were male and 9 cases were female, the median age was 8 years old and 1 month.Symptoms of the first episode included fever, drowsiness in 2 cases, visual acuity in 5 cases, convulsions in 3 cases, urinary retention in 2 cases, and ataxia in 2 cases.Abnormalities were found in 12 cases by the head magnetic resonance imaging(MRI), most of which showed extensive or isolated subcortical white matter lesions, and a few deep gray matter nuclei and brainstem were involved; 3 cases of spinal MRI abnormalities, mainly characterized by long segmental transverse myelitis; 6 cases optic nerve MRI abnormalities were found in 6 cases, manifested as disease side optic nerve or optic chiasm abnormal signals; the titer of serum MOG antibody was 110-1320 in 13 cases.All children responded well to glucocorticoids and gamma globulin, and all symptoms were alleviated after treatment.Two patients had recurrence during the follow-up period, which was characterized by optic neuritis.After azathioprine addition, there was no recurrence after 1 to 2 years of follow-up.
Conclusions:Children with MOG antibody encephalomyelitis present a decline in visual acuity commonly.The images are mainly acute disseminated encephalomyelitis-like changes, immunosuppressive therapy is effective, generally with a better prognosis.
