Effect of Dazhu Hongjingtian Capsule on Unstable Carotid Plaque with Qi Deficiency and Blood Stasis Syndrome
10.13422/j.cnki.syfjx.20190432
- VernacularTitle: 大株红景天胶囊对颈动脉不稳定斑块气虚血瘀证的干预分析
- Author:
Ying LIU
1
;
Ji-xiang HAN
1
;
Xiao-qin ZUO
1
;
Hui-ning XU
1
;
Jie LIU
2
;
Cheng-yu ZHAO
1
Author Information
1. Affiliated Hospital of Qinghai University, Xining 810001, China
2. Second People's Hospital of Xining, Xining 810014, China
- Publication Type:Research Article
- Keywords:
carotid atherosclerotic speckle;
unstable carotid plaque;
Dazhu Hongjingtian capsule;
anti-inflammation;
anti-oxidation;
antithrombotic formation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(4):128-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To discuss the effect of Dazhu Hongjingtian capsule to unstable carotid plaque (Qi deficiency and blood stasis syndrome), and its mechanisms in resisting oxidation, inflammation and thrombosis. Method: One hundred and twenty-three patients were randomly divided into control group (61 cases) and observation group (62 cases) by random number table. Patients in control group got aspirin enteric-coated tablets, 0.1 g/time, 1 time/day, and rosuvastatin calcium capsules, 10 mg/time, 1 time/day. In addition to the therapy of control group, patients in observation group were also given Dazhu Hongjingtian capsule, 4 grains/days, 3 times/days. And the outpatient follow-up was made once every 2 weeks for continued 16 weeks. Intima-media wall thickness (IMT), and number and size of plaque were detected by color Doppler ultrasound. And levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), superoxide dismutase (SOD), malondialdehyde (MDA), hypersensitive C reactive protein (hs-CRP), homocysteine (Hcy), matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of matrix metalloproteinase-2 (TIMP-2), platelet alpha granular membrane protein (GMP-140), P-selectin on surface of platelets (CD62 p), lysosome glycoprotein (CD63), and vascular pseudotumor factor (VWF) were detected. Qi deficiency and blood stasis syndrome were graded. Result: After treatment, IMT in observation group was thinner than that in control group, number of plaque was less than that in control group, and size of plaque was smaller than those in control group (P<0.01). After treatment, levels of LDL-C, hs-CRP, Hcy, MMP-2, MMP-9, MDA, GMP-140, vWF, CD62 p and CD63 were lower than those in control group (P<0.01), whereas levels of HDL-C and TIMP-2 were higher than those in control group (P<0.01). And scores of Qi deficiency and blood stasis syndrome were lower than those in control group (P<0.01). Conclusion: In addition to the treatment for resisting platelet and regulating blood lipid, Dazhu Hongjingtian capsule can lessen and reduce arterial speckle regulate lipid metabolism, ameliorate symptoms of traditional Chinese medical (TCM) syndrome, with effects in resisting oxidation, inflammation and thrombotic formation.
