Research Progress on Mechanisms of Vibration in Osteogenesis of Bone Mesenchymal Stem Cells
10.16156/j.1004-7220.2019.04.16
- VernacularTitle:微振动在骨髓间充质干细胞成骨向分化中的作用机制研究进展
- Author:
Anting JIN
1
;
Peng ZHANG
2
;
Yiling YANG
1
;
Lingyong JIANG
1
Author Information
1. Department of Oral and Maxillofacial Surgery Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
2. Second Dental Center, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, College of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
low-magnitude high-frequency vibration (LMHFV);
bone mesenchymal stem cells (BMSCs);
osteogenic differentiation;
mechanical stimulation;
signal transduction
- From:
Journal of Medical Biomechanics
2019;34(4):E440-E445
- CountryChina
- Language:Chinese
-
Abstract:
Vibration represents a micro reciprocating motion of a particle or object along a line or arc relative to a reference position, while the effect of low-magnitude high-frequency vibration (LMHFV) on skeletal system cells is similar to the mechanical stimulation of muscle movement. Bone mesenchymal stem cells (BMSCs), which have been identified as force-sensitive cells, exist in the bone marrows and have the potential of multi-lineage differentiation. Their biological characteristics can change functionally according to the appropriate stimulation in vitro, in order to reach the optimal demand of the stimulation. LMHFV can promote the osteogenic differentiation of BMSCs, therefore, the research on its mechanism can contribute to the application of vibration in the treatment of diseases such as osteoporosis, fracture, osteogenesis imperfecta, obesity as well as the promotion of orthodontic tooth movement. This paper summarizes the recent progress about the effects of vibration on BMSCs stem cells in osteogenesis and the possible mechanisms, so as to provide research ideas and methods for studying the mechanical as well as biological changes of BMSCs under vibration stimulation.
