Effects of Senescence on Mechanical Response of Osteocyte
10.16156/j.1004-7220.2019.03.18
- VernacularTitle:机体衰老对骨细胞力学响应的影响
- Author:
Jingke DU
1
;
Zhifeng YU
1
Author Information
1. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital， Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
mechanical response;
senescence;
osteocyte;
bone remodeling
- From:
Journal of Medical Biomechanics
2019;34(3):E333-E338
- CountryChina
- Language:Chinese
-
Abstract:
Bone is a dynamic organ, and the morphology, structure and function of bone can vary with the size, direction and form of mechanical stimulation. Appropriate mechanical stimulation is the key to maintain the dynamic balance of bone formation and bone resorption. However, with aging, the senescence of bone tissues causes a series of changes, including bone microenvironment, osteocyte morphology, signaling pathways in the osteocyte, etc., which weakens its mechanical response ability and then leads to osteoporosis and other diseases. Therefore, it is of great significance to study how aging affects the mechanical response of osteocyte. This review mainly discusses the influence of aging on mechanical response of the osteocyte.
