The Research Progress of Microfluidic Organ-on-Chips
10.16156/j.1004-7220.2019.03.16
- VernacularTitle:微流体器官芯片研究进展
- Author:
Haoran SU
1
,
2
;
Ping ZHAO
1
,
2
;
Xiaoyan DENG
1
,
2
;
Yubo FAN
1
,
2
;
Xiao LIU
1
,
2
Author Information
1. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University
2. Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University
- Publication Type:Journal Article
- Keywords:
microfluidic technology;
organ-on-chips;
drug screening
- From:
Journal of Medical Biomechanics
2019;34(3):E320-E326
- CountryChina
- Language:Chinese
-
Abstract:
Microfluidic technology refers to the technique of precise fluid control by manipulating submillimeter-scale fluids. In recent years, the use of microfluidic technology has realized the construction of organ-on-chips. The organ-on-chip refers to a micro-model with physiological functions, and cultivating living cells in a continuously perfused micro-chamber to simulate the physiological functions of tissues and organs. As the physiological function of the organ-on-chip has many advantages such as definite function, controllable microenvironment, rich measurement information, low chemical consumption, low cost, promising automation and high throughput, it has a huge application prospect in the field of drug development to solve the bottleneck problems in cellular and animal experiments, which has caused a great concern in the academic community. Although the organ-on-chip is still a very young research field, some microfluidic organ-on-chips have been developed and their potential applications are explored, including drug target optimization, drug screening and toxicity tests, and biomarker identification. In this review, the progress made in microfluidic organ microchips and their potential significance in clinical research were analyzed.
