Clinical Efficacy of Shensuyin in Treating Adult Viral Myocarditis with Syndrome of Insufficiency of Lung-Qi
10.13422/j.cnki.syfjx.20190531
- VernacularTitle: 参苏饮加减治疗肺气不足型成人病毒性心肌炎的临床观察
- Author:
Zhi-qiang LI
1
;
Xue-hui WANG
1
;
Hong-juan CHANG
2
Author Information
1. First Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, China
2. Nursing College of Xinxiang Medical College, Xinxiang 453108, China
- Publication Type:Research Article
- Keywords:
Shensuyin;
viral myocarditis;
syndrome of insufficiency of lung-qi;
Th17 cell;
Treg cell
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(5):73-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the efficacy of Shensuyin in treating viralmyocarditis (VMC) with syndrome of insufficiency of lung-qi and the effect on levels of Th17 and Treg cells and relevant factors. Method: One hundred-four VMC cases were regaded as object of study and randomly divided into control group and observation group, with 52 cases in each group. Control group was treated with routine therapy by reference to ‘Chinese Guidelines for Diagnosis and Treatment of Heart Failure 2014’. In addition to the therapy of control group, observation group on the basis of treatment in the control group with Shensuyin, 1 dose/d, bid. One course of treatment was 8 weeks for both groups. Scores of Shensuyin, serum levels of Troponin I (cTnI) and cardiac free fatty acid binding protein (H-FABP), heart function and total efficacy were compared for both groups. Flow cytometry was used to detect peripheral blood levels of Th17 and Treg cells for the two groups. Serum levels of interleukin (IL) -17, IL-21, IL-10 were detected in both groups. Result: After treatment, scores of syndrome of Yin and Yang deficiency (shortness of breath, fatigue, dull chest pain, bad breath, cough) of observation group were obviously lower than those of control group (P<0.01). Serum levels of H-FABP and cTnI of observation group were remarkably lower, while LVEF and E/A were higher than those of control group after treatment (P<0.01). Total efficacy of observation group was 92.16%, which was higher than 74% of control group (P<0.05). After treatment, peripheral blood levels of Th17 cell and Th17/Treg were obviously lower, while Treg cell was higher thancontrol group (P<0.01). Serum level of IL-17, IL-21 of observation group was remarkably lower, while IL-10 was higher than control group after treatment (P<0.01). Conclusion: In addition to the routine therapy of VMC, the efficacy of Shensuyin has a significant effect in treating VMC with syndrome of lung qi deficiency, and the regulatory effect on levels of Th17 and Treg cells and relevant factors may be one of the effective ways.
