Effects of Microenvironment on Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Cytoskeleton Tension
10.16156/j.1004-7220.2019.06.16
- VernacularTitle:微环境通过细胞骨架张力对骨髓间充质干细胞成骨分化的影响
- Author:
Hongyuan XU
1
;
Peng ZHANG
2
;
Lingyong JIANG
1
Author Information
1. College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Department of Oral and Maxillofacial Surgery, College of Stomatology，Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
2. College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Department of Oral and Maxillofacial Surgery, College of Stomatology，Second Dental Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
microenvironment;
cytoskeleton tension;
bone mesenchymal stem cells (BMSCs);
mechanotransduction
- From:
Journal of Medical Biomechanics
2019;34(6):E668-E672
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular matrix is the main element to provide mechanical clues for cells. The response of stem cells to mechanical signals is mainly achieved through the cytoskeleton. After mechanical signal is transmitted, cytoskeleton can form contractile microfilaments that actively generate tension through reorganization induced by microenvironment changes. The mechanical signals can regulate gene expression through either coupling with the nuclear skeleton directly or being transformed by the second message. Recent studies have proven that cytoskeleton tension has a series of impact on lineage specification, proliferation, differentiation and apoptosis of bone mesenchymal stem cells (BMSCs). BMSCs are of great significance in bone reconstruction and clinical treatment. The possible mechanisms about mechanotransduction and its effects of cytoskeleton tension on osteogenesis of BMSCs after micro-environmental changes were summarized.
