Clinical Effect of Wandaitang on Endometrial Carcinoma After Operation
10.13422/j.cnki.syfjx.201912433
- VernacularTitle: 完带汤辨治子宫内膜癌术后患者的临床分析
- Author:
Mei-ge QI
1
;
Li LI
1
;
Lin QI
1
;
Jing SONG
1
Author Information
1. Qinghai University Affiliated Hospital, Xining 810001, China
- Publication Type:Research Article
- Keywords:
endometrial carcinoma;
Wandaitang;
quality of life;
immune function;
tumor microenvironment
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(14):130-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of syndrome differentiation and treatment with Wandaitang on symptoms, quality of life and function of immunologic after operation of endometrial carcinoma (EC), in order to discuss the mechanism of action according to regulation of microenvironment of EC. Method:The 109 patients were divided into control group (54 cases) and observation group (55 cases) by random number table. Patients in control group got radiotherapy and/or chemotherapy according to different stages after operation. Patients in observation group were additionally given syndrome differentiation and treatment with Wandaitang, 1 dose/day. And a course of treatment was 3 months. Before and after treatment, symptoms, sign, functional assessment of cancer therapy-general (FACT-G) were scored. And levels of T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+), natural killer cell (NK), vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), insulin-like growth factor-1(IGF-1), interleukin-17 (IL-17) and IL-10 were detected. Result:After treatment, the scores of symptoms, signs and total scores of the patients in the observation group were lower than the control group (P<0.01).The scores of each dimension and total score of FACT-G scale in the observation group were higher than those in the control group(P<0.01). After treatment, NK, CD3 +, CD4 + and CD4 +/CD8 + in the observation group were higher than those in the control group(P<0.01),lower than the control group(P<0.01). After treatment, the serum levels of VEGF, TGF-β, IGF-1, IL-17 and IL-10 in the observation group were lower than those in the control group. Conclusion:Wandaitang can ameliorate clinical symptoms, improve quality of life of patients and immune function of organism, regulate multiple cytokines, change the tumor microenvironment of endometrial carcinoma.
