Analysis of Animal Model of Psoriasis Based on Clinical Characteristics of Traditional Chinese Medicine and Western Medicine
10.13422/j.cnki.syfjx.20191339
- VernacularTitle: 基于中西医临床病证特点的银屑病动物模型分析
- Author:
Rui ZHANG
1
;
Ming BAI
1
;
Ming-san MIAO
1
Author Information
1. Henan University of Chinese Medicine, Zhengzhou 450046, China
- Publication Type:Research Article
- Keywords:
psoriasis;
traditional Chinese and Western medicine;
clinical syndrome;
animal;
model
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(13):170-175
- CountryChina
- Language:Chinese
-
Abstract:
Based on the characteristics of clinical symptoms of psoriasis in traditional Chinese and Western medicine, and according to the coincidence between existing animal models and the characteristics of clinical symptoms of psoriasis in traditional Chinese and Western medicine, the evaluation criteria of psoriasis animal models are put forward, which can provide corresponding improvement ideas for psoriasis animal models. By listing the clinical manifestations and diagnostic criteria of psoriasis in traditional Chinese and Western medicine, this paper assesses the existing animal models of psoriasis, which accords with 8.3% of the clinical diagnostic criteria of Western medicine, 15% of the main symptoms and 8% of the secondary symptoms in traditional Chinese medicine. The results showed that imiquimod-induced model was found to be the best animal model with high coincidence. The rate of modeling was faster and the cost was lower, but it was reversible with the prolongation of withdrawal time. Allogeneic transplantation model and genotype model have high coincidence with Western medicine, but low coincidence with traditional Chinese medicine symptoms. Because psoriasis is a chronic, non-infectious skin disease that is prone to recurrence, there are many factors leading to psoriasis.The existing models can not simulate the clinical symptoms well. We should use multi-factor modeling method to establish a pathological model reflecting the characteristics of clinical symptoms of psoriasis in traditional Chinese and Western medicine combined with the main external pathogenic factors of psoriasis. Therefore, it is the main task for the future research of psoriasis traditional Chinese medicine to establish animal models that reflect the clinical characteristics of psoriasis and Western medicine and improve the evaluation criteria of psoriasis combined with syndrome animal models.
