Investigation of Decoction Process of Digda-4 Decoction
10.13422/j.cnki.syfjx.20190753
- VernacularTitle: 地格达-4味汤煎煮工艺考察
- Author:
Xiang TIAN
1
;
Rui-xue DING
1
;
Gen-na BA
2
;
Yu-xia BAI
2
;
Namujila LAXI
2
;
Da-yu CAI
3
;
Xiao-yong RAO
1
;
Xiao-jian LUO
1
Author Information
1. School of Pharmacy, National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China
2. School of Mongol Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China
3. Truking Technology Co. Ltd., Ningxiang 410600, China
- Publication Type:Research Article
- Keywords:
Digda-4 decoction;
aesculetin;
geniposide;
picroside Ⅰ;
picroside Ⅱ;
overall desirability;
decoction process
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(13):133-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the decoction process of Digda-4 decoction(DGD-4D), and provide reference for the standardization study of decoction of Mongolian medicine decoction. Method:Taking DGD-4D as model drug, different decoction methods of Mongolian medicine were compared, HPLC was used to determine contents of aesculetin, geniposide, picroside Ⅰ and picroside Ⅱ.On the basis of single factor tests, central composite design-response surface methodology was adopted to optimize the decoction process of DGD-4D with transfer rates of 4 components and dry extract rate as indexes, regression model fitting was carried out by Design-Expert 8.0.6 software, prediction model of process parameters was established, and the optimal process was verified. Result:The optimal decoction condition of DGD-4D was determined to be adding 40 times the amount of water and decocting for 17 min, decocting once.Transfer rates of aesculetin, geniposide, picroside Ⅰ, picroside Ⅱ and dry extract rate were 70.01%, 94.11%, 61.23%, 92.32%, 32.89%, respectively. Conclusion:The optimum decoction process of DGD-4D is established, it has important reference significance for excavating, sorting, improving the level of Mongolian medicine preparations and ensuring the consistency of their clinical efficacy.
