Effect of Modified Qingre Shenshi Tang on Inflammatory Factors, Oxidative Stress and Immune Function in Chronic Antral Sinusitis Patients with Damp-heat Pouring Downward Syndrome
10.13422/j.cnki.syfjx.20190623
- VernacularTitle: 清热渗湿汤加减对湿热下注型慢性肛窦炎患者炎症因子、氧化应激及免疫功能的影响
- Author:
Ning ZHANG
1
;
Xiao-li ZHOU
2
;
Shuai LIU
3
Author Information
1. Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China
2. The Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450008, China
3. Zhengzhou Yihe Hospital, Zhengzhou 450046, China
- Publication Type:Research Article
- Keywords:
modified Qingre Shenshi Tang;
chronic anal sinusitis;
inflammation;
oxidative stress;
immune function
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(13):93-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore effect of modified Qingre Shenshi Tang on inflammatory factors, oxidative stress and immune function in chronic antral sinusitis patients with damp-heat pouring downward syndrome. Method:A total of 94 cases of chronic antral sinusitis treated in our hospital from June 2017 to April 2018 were randomly divided into two groups, with 47 cases in each group. Control group was treated with metronidazole combined with gentamicin enema. In addition to the therapy of control group, the treatment group was given modified Qingre Shenshi Tang. The symptom scores, interleukin-2 (IL-2), IL-6, IL-8, tumor necrosis factor-α (TNF-α), gamma interferon (IFN-γ), super oxide dismutase (SOD), malondialdehyde (MDA), advanced oxidation protein products (AOPP), 8-hydroxy deoxyguanosine (8-OHDG), CD3+, CD4+, CD8+ levels of the two groups were observed before and after treatment, and the curative effect, reactions and relapse were observed. Result:After treatment, the total effective rates of treatment group(87.23%) and control group (78.72%) showed statistically significant differences (Z=2.067, P<0.05). The symptoms of anal pain, swelling and dampness in the treatment group were lower than those in control group (P<0.05). The levels of TNF-α, IL-6, IL-8, MDA, AOPP, 8-OHDG, CD8+in the treatment group were lower than those in control group (P<0.05), while the levels of IL-2, IFN-γ, SOD, CD3+, CD4+, CD4+/CD8+were higher than those in control group (P<0.05). After 3 months of follow-up, the recurrence rates of treatment group[4.26% (2/47)] and control group[21.28% (10/47)] were statistically significant (χ2=4.681, P<0.05). Conclusion:Modified Qingre Shenshi Tang has a good curative effect in the treatment of chronic antral sinusitis patients with damp-heat pouring downward syndrome by relieving symptoms, inhibiting inflammatory response, regulating oxidative stress, improving immune function and controlling recurrence rate.
