Photodynamic Therapy Results of Retinal Angiomatous Proliferation with Pigmented Epithelial Detachment in Age-related Macular Degeneration.
- Author:
Suk Ho BYEON
1
;
Jin Pyo HONG
;
Hyo LEE
;
Sang Jun OH
;
Sung Soo KIM
;
Hyoung Jun KOH
;
Sung Chul LEE
;
Oh Woong KWON
Author Information
1. Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. owkwon0301@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Age-related macular degeneration (ARMD);
Photodynamic therapy (PDT);
Pigmented epithelial detachment (PED);
Retinal angiomatous proliferation (RAP);
Visual outcome;
Neovascularization
- MeSH:
Age of Onset;
Angiography;
Epithelium;
Female;
Fluorescein Angiography;
Humans;
Hyperthermia, Induced;
Incidence;
Macular Degeneration*;
Photochemotherapy*;
Photography;
Retinaldehyde*;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2006;47(9):1410-1416
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the incidence of retinal angiomatous proliferation (RAP) and retinal pigmented epithelial detachment (PED) in Korean age-related macular degeneration (ARMD) patients and results of photodynamic therapy (PDT) with verteporfin. METHODS: Between May 2001 and December 2004, two hundred fifty-eight patients diagnosed of ARMD were evaluated and nine eyes of seven patients were as having RAP with PED. All patients underwent two or more sessions of PDT. Best-corrected visual acuity (BCVA), fundus photography, fluorescein angiography and ICG angiography were performed before and after treatment. RESULTS: The incidence of RAP with PED was 2.8%. The mean age of onset was 71.7 and five of seven patients were female. After 17 months and mean 2.3 PDT treatments, mean BCVA decreased from 0.2 to 0.04. In two eyes, additional Transpupillary thermotherapy was undertaken. Occlusion of RAP and flattening of PED was observed in one eye, and four evolved toward stage 3 RAP. Three eyes with PDT developed tear of retinal pigmented epithelium. CONCLUSIONS: Korean ARMD patients showed a low incidence of RAP and poor visual outcomes even with treatment.
