Clinical Effect of Dahuang Zhechong Wan on Pelvic Pain Caused by Endometriosis with Qi Stagnation and Blood Stasis Syndrome
10.13422/j.cnki.syfjx.20191231
- VernacularTitle: 大黄庶虫虫丸治疗子宫内膜异位症盆腔疼痛气滞血瘀证的临床观察
- Author:
Qiong FAN
1
;
Yu-na WEI
2
;
Ling YIN
1
;
Xu CHEN
3
Author Information
1. Panzhihua Second People's Hospital, Panzhihua 617068, China
2. Guangxi University of Traditional Chinese Medicine, Nanning 530200, China
3. Sichuan Maternal and Child Health Hospital, Chengdu 610045, China
- Publication Type:Research Article
- Keywords:
endometriosis;
pelvic pain;
Qi stagnation and blood stasis syndrome;
Dahuang Zhechong Wan;
prostaglandin;
proinflammatory factors;
matrix metalloproteinases
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(12):121-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To discuss the clinical effect of Dahuang Zhechong Wan on pelvic pain caused by endometriosis with Qi stagnation and blood stasis syndrome and study the mechanism of action. Method: One hundred and twenty-six patients were randomly divided into control group (64 cases) and observation group (62 cases) by random number table. Both groups' patients got Duphaston from the 5th to 25th days of menstrual cycle, 1 tablet/day, 2 times/days. Patients in control group got Sanjie Zhentong Jiaonang at the first day of menstruation, 4 grains/time, 3 times/days. Patients in observation group got Dahuang Zhechong Wan, 3 g/time, 2 times/days. The treatment in two groups continued for 3 menstrual cycles. Before treatment and at the first, second and third menstrual cycles after the treatment, visual analogue score (VAS) of pain was used for dysmenorrheal. Before AND after the treatment, scores of symptoms, signs, Qi stagnation and blood stasis syndrome and endometriosis were scored by endometriosis health profile-5 (EHP-5). And hemorheology was detected, and levels of matrix metalloproteinases-2 (MMP-2), MMP-9, tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), prostaglandin E2 (PGE2), prostaglandin F2α(PGF2α) and substance P (SP) were detected. Result: By rank sum test, the clinical effect of disease in observation group was better than that in control group (Z=2.198, P<0.05). At the first, second and third menstrual cycles, score of VAS was lower than that in control group (P<0.01). After treatment, scores of symptoms, signs, Qi stagnation and blood stasis syndrome and EHP-5 were lower than those in control group (P<0.01). And the ameliorate of hemorheological indices, such as the whole blood viscosity (high shear and low shear), plasma viscosity, erythrocyte sedimentation rate and platelet aggregation rate, were all better than those in control group (P<0.01). And levels of MMP-2, MMP-9, TNF-α, IL-1, PGF2α and SP were lower than those in control group (P<0.01), whereas level of PGE2 was higher than that in control group (P<0.01). Conclusion: In addition to treatment of progestogen, Dahuang Zhechong Wan can relieve pelvic pain, improve quality of life and clinical effect, and regulate levels of prostaglandins, matrix metalloproteinases and proinflammatory factors.
