Clinical Efficacy and 5-HT，VIP Levels of Hegan Granule in Treating Non-erosive Reflux Disease of Liver Depression and Spleen Deficiency
10.13422/j.cnki.syfjx.20191330
- VernacularTitle: 和肝颗粒治疗肝郁脾虚型非糜烂性反流病疗效及对5-HT,VIP的影响
- Author:
Li AN
1
;
Xiao-jing XIE
1
;
Ya-jie LI
1
;
Yue HUANG
1
;
Hong QUAN
1
Author Information
1. Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
- Publication Type:Research Article
- Keywords:
Hegan granule;
non-erosive reflux disease;
liver stagnation and spleen deficiency;
5-hydroxytryptamine;
vasoactive intestinal peptide;
Xiao Chaihutang;
Xiaoyaosan
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(12):110-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the clinical efficacy of Hegan granule in the treatment of non-erosive reflux disease with liver stagnation and spleen deficiency syndrome and its effect on quality of life, 5-hydroxytryptamine (5-HT) and vasoactive intestinal peptide (VIP) level. Method: Patients with non-erosive reflux disease of liver stagnation and spleen deficiency were randomly divided into treatment group (32 cases) and control group (33 cases). The treatment group was orally given Hegan granules after meal, 10 g/bag, 1 bag/time, 2 times/day. The control group was orally given with omeprazole enteric-coated tablets twice daily, 20 mg/grain. Both groups were treated for 8 weeks. The total scores of traditional Chinese medicine (TCM) symptoms, SF-36 health scale scores, 5-HT and VIP levels were observed before and after treatment. Result: The medical efficacy of the two groups was 87.5%and 81.8%in the treatment group and the control group, respectively. The treatment group was superior to control group (P<0.05). The treatment group had special symptoms and secondary symptoms after treatment, with better improvements than control group (P<0.05). The efficacy of the two groups was comparable in the main symptoms, after the treatment, the SF-36 health scale of treatment group in physiological function, overall health, vitality, social function, emotional function and mental health were higher than those in control group (P<0.05). The levels of 5-HT and VIP in two groups were lower after treatment, and treatment group was significantly lower than control group (P<0.05). Conclusion: Hegan granule has a good clinical efficacy in treating patients with non-erosive reflux disease and liver stagnation and spleen deficiency. It can significantly alleviate the symptoms of TCM, improve the quality of life of patients, and reduce the sensitivity of esophageal viscera.
