Application Status of Properties of Surface and Interface in Research on Pharmaceutical Preparations
10.13422/j.cnki.syfjx.20190208
- VernacularTitle: 表界面特性在药物制剂研究中的应用现状
- Author:
Jia-xuan LI
1
;
Xiao-hong SHI
1
;
Li-jie ZHAO
1
;
Yi FENG
1
;
Ruo-fei DU
1
;
Yan-long HONG
1
;
You-jie WANG
1
Author Information
1. Engineering Research Center of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Innovation Research Institute of TCM, Shanghai Innovation Center of TCM Health Service, Shanghai University of TCM, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
pharmaceutic preparations;
specific surface area;
surface tension;
surface free energy;
interfacial action;
emulsion;
solubilization
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(11):216-223
- CountryChina
- Language:Chinese
-
Abstract:
The surface and interface,as the transition region between two phases,belongs to the category of physical chemistry.At present,it is widely used in materials and other scientific fields.Meanwhile,this property also plays an important role in pharmaceutical research.The interface layer involved in the progress of pharmaceutical preparations is connected with the two-phase or three-phase between gas,liquid and solid closely.The interface effect will affect the final shaping of pharmaceutical preparations and the dissolution and absorption of drugs in the human body.In this paper,the surface and interface characteristics(specific surface area,surfacial and interfacial tension and surface Gibbs free energy) were compared,and the application of interface phenomena(wetting,solubilization and emulsification) in pharmaceutical research were introduced.From the points of view of the progress control of pharmaceutical preparations and the effectiveness of their products,the article expounds the important role of properties of surface and interface in the field of pharmaceutical preparations.Therefore,it is necessary to pay attention to the properties of surface and interface,one of the key physical properties of drugs,and to apply them in the pharmaceutical research.