Preparation of Self-emulsifying Preparations of Chinese Medicinal Ingredients Based on Identical Carrier System and Investigation of Their Transdermal Absorption Characteristics in Vitro
10.13422/j.cnki.syfjx.20190315
- VernacularTitle: 基于相同载体体系的中药成分自乳化制剂的制备及其体外透皮吸收特性考察
- Author:
Jing-xian LIANG
1
;
Shao-wa LYU
1
;
Ting ZHU
1
;
Xian-tong GUAN
1
;
Yuan-qun WU
1
;
Yong-ji LI
1
;
Ying-peng LI
2
Author Information
1. Heilongjiang University of Chinese Medicine, Harbin 150040, China
2. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
- Publication Type:Research Article
- Keywords:
self-emulsifying;
powder;
transdermal absorption characteristics;
baicalein;
berberine;
allicin;
matrix prescription
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(11):121-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare self-emulsifying carrier system which was suitable for three Chinese medicinal ingredients(baicalein,berberine and allicin),and investigate transdermal absorption effect in vitro of these three self-emulsifying preparations. Method:The optimum formulation and dosage were screened by the saturated solubility method,pseudo-ternary phase diagram method and orthogonal experiment.Transdermal absorption test in vitro was carried out with excised rats skin and Franz diffusion cell.The cumulative penetration amounts of baicalein,berberine and allicin in the identical self-emulsifying system were determined by HPLC and compared with baicalein powder,berberine powder and allicin powder,respectively. Result:The optimum formulation was ethyl oleate-cremophor RH40-polyethylene glycol(PEG)400.The self-emulsifying preparation had a suitable particle size with a relatively regular spherical shape.At 10 h of transdermal absorption,the transdermal rates of baicalein,berberine and allicin in identical self-emulsifying system were 6.898 6,7.600 4,190.040 μg·cm-2·h-1,the cumulative penetration amounts of them were 71.38,85.54,1 795.16 μg·cm-2,respectively. Conclusion:The self-emulsifying carrier system is prepared successfully,which can be used by different kinds of Chinese medicinal ingredients,and the transdermal absorption effect in vitro of these self-emulsifying preparations is good,which can provide experimental basis for the preparation and transdermal absorption of self-emulsifying preparation of Chinese herbal compound.
