Influence of Shengmaiyin Combined with Xuefu Zhuyu Tang on Hypercoagulable State Caused by Non-small Cell Lung Cancer
10.13422/j.cnki.syfjx.20191132
- VernacularTitle: 生脉饮合血府逐瘀汤对非小细胞肺癌血液高凝状态的影响
- Author:
Lan ZHANG
1
;
Lei SONG
1
;
De-xu LI
1
;
Ya-wei LIU
1
;
Yong-chen ZHAO
1
;
Gui-min YANG
2
;
Min TANG
3
Author Information
1. The Affiliated Hospital of Hebei University, Baoding 071006, China
2. Baoding First Hospital, Baoding 071015, China
3. Baoding Children's Hospital, Baoding 071011, China
- Publication Type:Research Article
- Keywords:
non-small cell lung cancer;
hypercoagulable state;
Qi deficiency and blood stasis syndrome;
Shengmaiyin;
Xuefu Zhuyu Tang
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(11):109-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe influence of dialectical addition and subtraction of Shengmaiyin combined with Xuefu Zhuyu Tang on fibrinolytic activity and coagulation active factor of patients with non-small cell lung cancer at hypercoagulable state. Method:One hundred and eighty patients were randomly divided into control group (58 cases) and observation group (60 cases) by random number table. Patients in control group got low molecular weight heparins calcium injection by subcutaneous injection for 3 weeks, 1.0 mL (5 000 AXa unit)/time, 1 time/day, and oral aspirin enteric-coated tablets, 100 mg/time, 1 time/day. Patients in observation group got dialectical addition and subtraction of Shengmaiyin combined with Xuefu Zhuyu Tang, 1 dose/day. A course of treatment was 8 weeks. And activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), platelet (PLT), fibrinogen (FIB), D-dimer (D-D), plasma tissue plasminogen activator (t-PA), plasminogen activator inhibitor in plasma-1 (PAI-1), von willebrand factor (vWF), P-selectin, basic fibroblast growth factor (bFGF), transforming growth factor (TGF), vascular endothelial growth factor (VEGF) were detected. And before and after treatment, scores of Qi deficiency and blood stasis syndrome and hemorheological indices were detected. Result:After treatment, APTT, PT and TT in observation group were longer than those in control group. Levels of PLT, D-D and PAI-1 were lower than those in control group (P<0.01), level of t-PA was higher than that in control group (P<0.01). And levels of vWF, P-selectin, bFGF, TGF and VEGF were lower than those in control group (P<0.05, P<0.01). And improvement of hemorheological indexes the such as the whole blood viscosity (high shear and low shear), plasma viscosity and platelet aggregation rate were better than those in control group (P<0.01). And scores of symptoms of Qi deficiency were lower than those in control group (P<0.01), and except for ‘zhengji’, scores of symptoms of blood stasis were lower than those in lower than those in control group (P<0.01). Conclusion:Dialectical addition and subtraction of Shengmaiyin combined with Xuefu Zhuyu Tang can ameliorate hypercoagulable state of NSCLC, relieve clinical symptoms, and can regulate fibrinolytic activity and coagulation activity factors, so it can mitigate dangers caused by deep venous thrombosis of NSCLC.
