Clinical Efficacy of Jianpi Qingchang Decoction in Treating Patients with Spleen Deficiency Damp-heat Hormone-dependent Ulcerative Colitis
10.13422/j.cnki.syfjx.20190829
- VernacularTitle: 健脾清肠方治疗脾虚湿热型激素依赖溃疡性结肠炎患者的临床疗效
- Author:
Ya-li ZHANG
1
;
Qian GUO
1
;
Lie ZHENG
2
;
Yan-cheng DAI
1
;
Zhi-peng TANG
1
Author Information
1. Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine(TCM), Shanghai 200032, China
2. Shaanxi TCM Hospital, Xi'an 710003, China
- Publication Type:Research Article
- Keywords:
Jianpi Qingchang decoction;
spleen deficiency damp-heat type;
hormonal dependence;
ulcerative colitis;
clinical efficacy evaluation;
Shengling Baizhu San;
Diyusan
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(10):69-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy of Jianpi Qingchang decoction in the treatment of spleen deficiency and damp-heat hormone-dependent ulcerative colitis and explore its possible target. Method:A total of 60 patients with spleen deficiency and damp-heat hormone-dependent ulcerative colitis were selected and collected from the outpatient department and the inpatient department of Longhua Hospital affiliated to Shanghai University of Chinese Medicine on April 31, 2012.Two groups were given the basic therapy of prednisone, and control group received orally bolus for spleen and spleen and intestines, 6 g/time, 3 times/d. The treatment continued for three months. The experimental group was given orally Jianpi Qingchang decoction, 1 dose per day, and 300 mL water decoction, 150 mL each time, 2 times/d, and took at different temperatures in the morning and evening. The treatment continued for three months. After treatment, changes in intestinal symptom score, traditional Chinese medicine (TCM) syndrome score and endoscopic score of two groups were observed. Result:Compared with before treatment, the symptom scores of diarrhea, mucous purulent in control group were significantly reduced after treatment (P<0.01). The scores of mucous purulent and bloody stool, diarrhea, abdominal pain, and tenesmus were significantly reduced in experimental group (P<0.01), and the scores of mucous purulent and bloody stool, and symptom of diarrhea were significantly decreased in experimental group after treatment than that of control group (P<0.01). Before treatment, the scores of TCM syndromes in two groups were compared, with no statistically significant difference. After treatment, the scores of TCM syndromes of two groups were significantly reduced (P<0.01), and the reduction of the experimental group was more significant than that of control group (P<0.05). Compared with before treatment, the endoscopy scores of two groups were significantly reduced after treatment (P<0.01), and the decrease of the experimental group was more significant than that of control group (P<0.01). Mayo scores were significantly reduced in both groups after treatment compared with that before treatment (P<0.01), and significantly reduced in the experimental group compared with control group (P<0.05). Conclusion:Jianpi Qingchang decoction can effectively improve mucous purulent stool and diarrhea symptoms in patients with spleen deficiency and damp-heat hormone-dependent ulcerative colitis, and reduce TCM syndrome score and endoscopic score, and thus is worthy of clinical reference and promotion.
