Advances in Studies on Chinese Materia Medica for Treatment of Sepsis Based on NF-κB Signal Pathway
10.13422/j.cnki.syfjx.20190706
- VernacularTitle: 基于NF-κB信号通路的中药治疗脓毒症研究进展
- Author:
Yu-lu MIAO
1
;
Wen-zhi ZHANG
1
;
Wen-xia ZHANG
2
;
Min FENG
2
;
Yong-hua YUE
1
;
Chun-xia NIE
2
;
Yan NI
1
Author Information
1. Shanxi Provincial Academy of Traditional Chinese Medicine, Taiyuan 030045, China
2. Shanxi University of Chinese Medicine, Taiyuan 030619, China
- Publication Type:Research Article
- Keywords:
nuclear factor kappa B(NF-κB) signal pathway;
sepsis;
three syndrome patterns and three treatments;
compound Chinese materia;
single herb;
active ingredient;
Chinese patent medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(9):214-220
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a kind of systemic inflammatroy response syndrome (SIRS) induced by severe infection,operation,and trauma,with high mortality rate,treatment cost,and high consumption of medical resources.It has caused a great burden to the medical industry and even the national economy.Therefore,it is urgent to find effective treatment methods for sepsis.At present,the sepsis has been treated with certain drugs pointing at its pathogenesis,such as antibiotics,glucocorticoids,and vasoactive drugs.,but the therapeutic effect is not ideal,with many side effects,poor prognosis,and high clinical mortality.Based on the overall macro-dialectical thinking mode,and with the unique effect and low side effect,traditional Chinese medicine (TCM) has attracted the attention from researchers and clinicians around the world for treatment of sepsis.In recent years,some traditional Chinese medicine prescriptions,Chinese patent medicines,single Chinese medicines and active ingredients are increasingly used as new drugs to prevent and treat sepsis.Such treatment methods have been widely recognized and have reduced the mortality and inflammatory indexes of patients to a certain extent,playing an important role in the prevention and treatment of sepsis.In this paper,the actions of nuclear factor kappa B (NF-κB) signal pathway in sepsis as well as the advances in research of NF-κB signal pathway-related proteins in Chinese medicine for sepsis were reviewed.
