Isolation and Elucidation of a Novel Isoquinoline Alkaloid from Corydalis hendersonii
- VernacularTitle: 矮紫堇中1个新的异喹啉生物碱分离与鉴定
- Author:
Sha-na WUKEN
1
;
Xu YIN
1
;
Jiu MI
1
;
Shun-gang JIAO
1
;
He-xin-ge ZHANG
1
;
Xiao-chun ZHOU
1
;
Peng-fei TU
1
;
Xing-yun CHAI
1
;
Chun-sheng LIU
1
Author Information
- Publication Type:Research Article
- Keywords: Corydalis hendersonii; isoquinoline alkaloid; hendersine G; Tibetan medicine; succinic acid; anti-myocardial ischemia; pharmacodynamic substances
- From: Chinese Journal of Experimental Traditional Medical Formulae 2019;25(9):172-175
- CountryChina
- Language:Chinese
- Abstract: As part of systematic research of Corydalis hendersonii,a typical traditional Tibetan herbal medicine with clearing heat,relieving pain,and lowering blood pressure effects,a novel isoquinoline alkaloid,named hendersine G was isolated from the ethanol extract of the whole plant by various chromatographic techniques,including silica gel column,reverse phase column (ODS),Sephadex LH-20,and semi-preparative HPLC.Its structure was elucidated by MS,NMR and other spectroscopic data analysis.Hendersine G can be regarded as a condensation product of a tetrahydroberberine and a succinic acid,however,its absolute configuration has not been determined due to its structural complexity and less obtained amount.This present study provides an inspiration for further exploration of novel molecules from C.hendersonii.
