Clinical Observation of Addition and Subtraction Therapy of Shentong Zhuyutang to Myofascial Pain Syndrome (MPS) with Stagnation of Blood Stasis
10.13422/j.cnki.syfjx.20190932
- VernacularTitle: 身痛逐瘀汤加减治疗瘀血阻滞型腰背肌筋膜疼痛综合征的临床观察
- Author:
Hua-liang ZHU
1
;
Zong-bo ZHOU
1
;
Xu-gang WU
1
;
Zhi-fu LU
1
;
Li-tao LIU
1
Author Information
1. Haikou Hospital of Traditional Chinese Medicine, Haikou 570216, China
- Publication Type:Research Article
- Keywords:
myofascial pain syndrome;
stagnation of blood stasis;
Shentong Zhuyutang;
recurrence;
thromboxane 2;
6-ketone-prostaglandin F1α
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(9):49-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the short and long term effect of addition and subtraction therapy of Shentong Zhuyutang to myofascial pain syndrome (MPS) with stagnation of blood stasis and to investigate its mechanism of action.Method: One hundred and forty-eight eligible patients were randomly divided into control group (73 cases) and observation group (75 cases) by random number table.Patients in both groups got electroacupuncture treatment.Patients in control group additionally got Yaotong capsules,4 grains/time,3 times/day.Patients in observation group additionally got addition and subtraction therapy of Shentong Zhuyutang,1 dose/day.The treatment was continued for 6 weeks in both groups,and 16 weeks follow-up was recorded.Before treatment,and at the 1st,2nd,3rd,4th,5th,6th week after treatment,scores of visual analogue scale (VAS) was graded.Before and after treatment,scores of JOA,Roland-Morris disability questionnaire (RDQ),body damage index assessment scale (PⅡ scale),stagnation of blood stasis,and Pittsburgh sleep quality index (PSQI) were graded.Levels of thromboxane 2(TXB2),6-ketone-prostaglandin F1α(6-keto-PGF1α) were detected,and TXB2/6-keto-PGF1α was calculated;in addition,the recurrence was recorded and followed up.Result: By rank sum test,the clinical efficacy in observation group was better than that in control group (Z=1.969,P<0.01).Analysis of variance of repeated measures indicated that,scores of VAS were decreased gradually at the 1st,2nd,3rd,4th,5th,6th week in both groups after treatment (Fcontrol=5.801,Fobservation=6.649,P<0.05).Paired t-test indicated that scores of VAS in observation group were lower than those in control group at 2nd,3rd,4th,5th,6th week (P<0.01).Scores of three dimensions of JOA scale and total score in observation group were higher than those in control group (P<0.01).Scores of RDQ,PⅡ,PSQI,stagnation of blood stasis,whole blood viscosity (high cut and low cut),plasma viscosity,fibrinogen,TXB2,and T/K in observation group were lower than those in control group (P<0.01),and level of 6-keto-PGF1α was higher than that in control group (P<0.01).In addition,the recurrence rate in observation group was 12%,lower than 26.03% in control group (χ2=4.745,P<0.05).Conclusion: Based on acupuncture treatment,addition and subtraction therapy of Shentong Zhuyutang can relieve the pain caused by myofascial pain syndrome (MPS) with stagnation of blood stasis,recover lumbar activity function,reduce rate of recurrence,and ameliorate blood circulation,with anti-inflammatory and analgesia effects.
