Potential Mechanism of Jiaotaiwan for Diabetes Based on Integrative Pharmacology Method
10.13422/j.cnki.syfjx.20190807
- VernacularTitle: 基于整合药理学策略的交泰丸治疗糖尿病的潜在机制分析
- Author:
Can-can DUAN
1
;
Xian WU
2
;
Wen-bi MU
2
;
Sha YANG
2
;
Qi-hong CHEN
2
;
Kuan CHEN
2
;
Jian-yong ZHANG
2
Author Information
1. Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563003, China
2. School of Pharmacy, Zunyi Medical University, Zunyi 563009, China
- Publication Type:Research Article
- Keywords:
Jiaotaiwan;
integrative pharmacology;
diabetes;
potential mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(8):133-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Jiaotaiwan is a classic prescription in traditional Chinese medicine for insomnia. Modern clinical research has proved its anti-diabetes effect by "the same treatment for different diseases" theory, so it is necessary to study its pharmacological mechanism for anti-diabetes effect. Method: In this study, the integrative pharmacology platform of traditional Chinese medicine (TCMIP) was used to explore the potential target and mechanism of Jiaotaiwan, and construct its core target network for diabetes. Then the enrich analysis of GO and KEGG on key targets was conducted to build the visual multilayer association network of "Jiaotaiwan-active composition-core target-key pathway". Result:28 active ingredients were obtained from Jiaotaiwan in this study. Its anti-diabetes effect was relevant to 187 core targets,including 15 known disease targets such as vasopressin V2 receptor (AVPR2), receptor activity-modifying protein 1 (RAMP1), receptor activity-modifying protein 3 (RAMP3), insulin receptor (INSR), and insulin-like growth factor 1 receptor (IGF1R); as well as 71 predictive drug targets such as cyclin-dependent kinase 9 (CDK9), glucokinase (GCK), NF-kappa-B inhibitor alpha (NFKBIA), NF-kappa-B p100 subunit (NFKB2), and hypoxia inducible factor-1 alpha (HIF1A). Conclusion:The anti-diabetes mechanism of Jiaotaiwan may be associated with activation of adenylate cyclase activity, cellular response to glucagon stimulus, activation of mitogen-activated protein kinase (MAPK) activity, endocrine system, gonadotropin-releasing hormone (GnRH) signaling pathway, Chemokine signaling pathway, phosphatidylinositol 3-kinase-serine/threonine kinases (PI3K-Akt) signaling pathway and other related biological processes and pathways. This study provides a scientific evidence for further study of the anti-diabetes mechanism of Jiaotaiwan.
