Discussion About Application of Thin Layer Chromatography in Current Quality Standard Control
10.13422/j.cnki.syfjx.20190202
- VernacularTitle: 薄层色谱法在当前中药质量标准中的应用探讨
- Author:
Zhe DENG
1
;
Wen-guang JING
2
;
An LIU
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
2. China National Traditional Chinese Medicine Co. Ltd., Beijing 102600, China
- Publication Type:Research Article
- Keywords:
thin layer chromatography;
quality standards;
high performance liquid chromatography;
Chinese Pharmacopoeia;
characteristic spectrum
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(7):201-206
- CountryChina
- Language:Chinese
-
Abstract:
The application of thin layer chromatography(TLC) in Chinese Pharmacopoeia experienced from scratch to less to more,but the proportion of thin layer chromatographic scanning used in recent editions of Chinese Pharmacopoeia has decreased.With the further improvement of the quality standard system of traditional Chinese medicine(TCM),the shortcomings of TLC identification methods have been gradually revealed,such as the low penetration rate of instrument,poor repeatability and stability of the results,lower identification speed than high performance liquid chromatography(HPLC) and so on.Thus it gradually became untimely.In the process of formulating quality standard control of TCM,researchers should not be conformist,and TLC identification should not be a necessary choice for the qualitative identification.And HPLC has the possibility to completely replace TLC,but TLC can be used as a supplement to HPLC.In order to fully lower testing cost,shorten testing cycle,improve the efficiency of identification,we suggested quality standard system of TCM should be sharply reduced TLC identification method and increased identification of HPLC characteristic spectrum;and try to do "one condition,one map".Unless absolutely necessary,national quality standards(such as Chinese Pharmacopoeia) should use TLC identification as a recommended method rather than a mandatory standard.
