Effect of Jieyu Tongluo Method in Regulating Levels of Neurotransmitter from Patients with Post-stroke Depression
10.13422/j.cnki.syfjx.20190732
- VernacularTitle: 解郁通络法对脑卒中后抑郁患者神经递质水平的影响
- Author:
Qing-li LI
1
;
Gui-xian WANG
1
;
Yan-jie WANG
1
;
Ming YANG
1
;
Zhong-feng XUE
2
Author Information
1. The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, China
2. Guangxi University of Traditional Chinese Medicine, Nanning 530001, China
- Publication Type:Research Article
- Keywords:
post-stroke depression;
Jieyu Tongluo decoction;
Sinisan;
Taohong Siwutang;
neurotransmitter;
nerve function;
activities of daily living
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(7):134-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the clinical efficacy of Jieyu Tongluo decoction on post-stroke depression (PSD) and its regulatory effect on neurotransmitter. Method: One hundred and twenty-five patients with PSD were randomly divided into control group (62 cases) and observation group (63 cases) by random number table. Both groups got psychological support, health education, and sertraline hydrochloride tablets, 25-50 mg/time, 2 times/days. Patients in control group got Shugan Jieyu capsules, 2 grains/time, 2 times/days. Patients in observation group got Jieyu Tongluo decoction, 1 dose/day. And a course of treatment was 6 weeks. Before and after treatment, hamilton depression scale (HAMD-17), patient health questionnaire-9 (PHQ-9), national institutes of health stroke scale (NHISS),traditional Chinese medicine(TCM) syndrome and activity of daily living scale (ADL) were scored. And levels of 5-serotonin (5-HT), norepinephrine (NE), dopamine (DA), brain-derived neurotrophic factor (BDNF), serum S100-β and neuron enolase (NES) were detected. Result: By rank sum test, after treatment, the clinical efficacy of observation group was superior to that in control group (Z=2.384, P<0.01). Scores of HAMD-17 and PHQ-9 were lower than those in control group (P<0.01). Score of HAMD-17 was lower than that in control group (Z=2.266, P<0.05), and score of PHQ-9 was lower than that in control group (Z=2.817, P<0.05). And scores of NHISS, TCM syndromes, serum S100 β and neuron enolase (NES) were lower than those in control group (P<0.01), while levels of ADL, 5-HT, DA, NE and BDNF were all higher than those in control group (P<0.01). Conclusion: In addition to psychotherapy and SSRI, Jieyu Tongluo decoction can relieve degree of depression, depressive symptoms and degree of neurologic impairment, increase activities of daily living, regulate neurotransmitter expression, and improve the reparation of cranial nerve tissue, with obvious clinical effects, and is worthy to be used in clinic.
