Clinical Observation of Modified Wufu Maxin Guijiang Decoction Treatment to Chronic Nonspecific Low Back Pain (NLBP) with Syndrome of Cold Dampness and Stasis
10.13422/j.cnki.syfjx.20190831
- VernacularTitle: 加味乌附麻辛桂姜汤治疗慢性非特异性下腰痛寒湿瘀阻证的临床观察
- Author:
Yan CAI
1
;
Zong-bo ZHOU
2
;
Shu-hong GUI
1
;
Gui-zhu CHEN
1
;
Yu-ling LI
1
;
Jia-min ZHU
1
Author Information
1. Hainan Provincial People's Hospital, Haikou 570000, China
2. Haikou Hospital of Traditional Chinese Medicine, Haikou 570216, China
- Publication Type:Research Article
- Keywords:
nonspecific low back pain;
syndrome of cold dampness and stasis;
modified Wufu Maxin Guijiang decoction;
recrudescence
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(7):128-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the short-term and long-term clinical effect of modified Wufu Maxin Guijiang decoction treatment to chronic nonspecific low back pain (NLBP) with syndrome of cold dampness and stasis, and to investigate the mechanism of anti-inflammatory and analgesia. Method: One hundred and nineteen eligible patients were randomly divided into control group (59 cases) and observation group (60 cases) by random number table. Patients in control group got acupuncture treatment and pilates. Based on the treatment in control group, patients in observation received additional modified Wufu Maxin Guijiang decoction, 1 dose/day. The course of treatment was 6 weeks in both groups. Before and after treatment, scores of short-form McGill pain questionnaire (SF-MPQ), Oswestry disability index (ODI), Japanese orthopaedic association (JOA) and syndrome of cold dampness were graded. After treatment, the patients made self efficacy assessment. Levels of thromboxane 2 (TXB2), 6-Keto-PGFla, tumor necrosis factor-α(TNF-α) and interleukins-1β(IL-1β) were detected both before and after treatment. Result: After treatment, the rank sum test showed that the clinical efficacy in observation group was better than that in control group (Z=2.226, P<0.05), and the self efficacy assessment showed the efficacy in observation group was also better than that in control group(Z=2.104, P<0.05). Scores of SF-MPQ, PRI, VAS, PPI, ODI and syndrome of cold dampness and stasis in observation group were all lower than those in control group (P<0.01), and score of JOA was higher than that in control group (P<0.01). Levels of TXB2, TNF-α and IL-1β and TXB2/6-Keto-PGFla were lower than those in control group (P<0.01), and the level of 6-Keto-PGFla was higher than that in control group (P<0.01). Conclusion: Based on the acupuncture treatment and pilates, modified Wufu Maxin Guijiang decoction in the treatment of chronic NLBP can ameliorate symptoms of pain, promote the recovery of function, and enhance activity of daily living in a short term, reduce the recurrence and stabilize the disease condition in a long term, with certain effects of anti-inflammatory and analgesia.
