Clinical Effect of Shugan Granule on Depression of Liver Qi Stagnation Type in Perimenopausal Period
10.13422/j.cnki.syfjx.20190631
- VernacularTitle: 舒肝颗粒治疗围绝经期肝郁气滞型抑郁症的疗效观察
- Author:
Gui-xian WANG
1
;
Mai-hui CHANG
1
;
Qing-li LI
1
;
Yong-xin CHEN
1
Author Information
1. Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, China
- Publication Type:Research Article
- Keywords:
perimenopausal depressive disorder;
Shugan Granule;
sex hormone;
brain derived neurotrophic factor;
pro-inflammatory factor
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(6):114-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy of Shugan granule on perimenopausal depressive disorder (stagnation of liver Qi and Qi stagnation) and its effect on sex hormone and inflammatory factors. Method:One hundred and twenty patients were randomly divided into control group (60 cases) and observation group (60 cases) by random number table. Both groups got Tibolone tablets, 2.5 mg/time, 1 time/day. Patients in control group got flupentixol and melitracen tablets once every morning and noon, 1 tablet/time. In addition to the therapy of control group, patients in observation group got Shugan granule, 1 pack/time, 2 times/days. And a course of treatment was 8 weeks. Main indexes were graded by Hamilton depression scale (HAMD-17), self-rating depression scale (SDS) and Eysenck Personality Questionnaire (EPQ). And secondary indexes were scored by self-rating anxiety scale (SAS), stagnation of liver Qi and Qi stagnation, improved kupperman (KI), levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), 5-serotonin (5-HT), brain derived neurotrophic factor (BDNF), interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) before and after treatment. Result:By rank sum test, the clinical efficacy on depressed and perimenopausal syndrome in observation groups was better than that in control group (Z=2.038, P<0.05, Z=2.316, P<0.05).Scores of HAMD-17, SDS, EPQ-N, SAS, KI and stagnation of liver qi and qi stagnation were lower than those in control group (P<0.01), whereas score of EPQ-E was higher than that in control group (P<0.01). And levels of FSH, LH, IL-1β, IL-6 and TNF-α were lower than those in control groups (P<0.01). Levels of E2, BDNF and 5-HT were higher than those in control groups (P<0.01). Conclusion:Shugan granule can relieve depression, inquietude and symptoms caused by perimenopausal syndrome, regulate sex hormone, 5-HT, BDNF and inflammatory reaction, with a better clinical effect than pure western medicine treatment.
