Clinical Efficacy of Xiaoxuan Zhiyun Tablet in Treating Cervical Vertigo with Syndrome of Phlegm and Blood Stasis Resistance
10.13422/j.cnki.syfjx.20190632
- VernacularTitle: 消眩止晕片治疗颈性眩晕痰瘀内阻证的临床观察
- Author:
Cheng-lin DONG
1
;
Jing DING
1
;
Jing WANG
1
;
Yu-feng DING
1
Author Information
1. Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- Publication Type:Research Article
- Keywords:
Xiaoxuan Zhiyun tablet;
cervical vertigo;
syndrome of phlegm and blood stasis resistance;
oxidative stress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(6):108-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy of Xiaoxuan Zhiyun tablet in treating cervical vertigo with syndrome of phlegm and blood stasis resistance and its effect on oxidative stress and serum levels of endothelin-1(ET-1), 5-hydroxytryptamine (5-HT), and nitric oxide (NO). Method:One hundred eighteen cervical vertigo cases were selected and randomly divided into control group (59 cases) and treatment group (59 cases) by random number table. Control group was given bone setting combined with acupuncture. In addition to the therapy of control group, treatment group was given Xiaoxuan Zhiyun tablet (1 dose/day, tid). Both groups were treated for 3 weeks. Scores of cervical vertigo symptom and function assessment scale (ESCV) and vertigo disorder scale (DHI), blood velocity of vertebrobasilar artery, life quality and efficacy were compared between both groups. Serum levels of superoxide dismutase (SOD), malondialdehyde (MDA), ET-1, 5-HT and NO were detected in both groups. Result:After treatment, ESCV score of treatment group was obviously higher, while DHI score was lower than control group (P<0.01). Blood flow velocity of left vertebral artery, right vertebral artery and basilar artery in treatment group were obviously higher than those of control group after treatment (P<0.01). Total clinical efficacy of treatment group wsa 98.25%, which was superior to 83.93% of control group (P<0.05). After treatment, SF-36 index score was remarkably higher than that of control group (P<0.01). Serum levels of SOD and NO of treatment group were higher, while MDA, ET-1,5-HT were lower than control group (P<0.01). Conclusion:In addition to the routine therapy, the efficacy of Xiaoxuan Zhiyun tablet in treating cervical vertigo is significant, which may be related with regulation of oxidative stress and serum levels of ET-1, 5-HT and NO.
