Discovery and Application of Quality Marker of Traditional Chinese Medicine Based on Integrative Pharmacology
10.13422/j.cnki.syfjx.20190546
- VernacularTitle: 基于整合药理学的中药质量标志物发现与应用
- Author:
Hai-yu XU
1
;
Wen-bin HOU
2
;
Ke LI
3
;
Ye SHEN
4
;
Shi-huan TANG
1
;
Fei-fei GUO
1
;
Jing-jing ZHANG
1
;
Hong-wei WU
1
;
Ping WANG
1
;
Jin SU
1
;
Rong-rong ZHOU
5
;
Ya-zhuo LI
2
;
Lan WANG
1
;
Lei WANG
3
;
Lei-lei GONG
1
;
Hong-jun YANG
1
;
Chang-xiao LIU
2
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
2. Research Center for New Drug Evaluation, National Key Laboratory of Drug Release Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
3. Key Laboratory of Ultrawideband & Tera-Hertz of Shandong Academy of Sciences, Institute of Automation, Qilu University of Technology(Shandong Academy of Sciences), Ji'nan 250014, China
4. National Resource Center for Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences, Beijing 100700, China
5. School of Basic Medical Sciences, Shanxi University of Chinese Medicine, Jinzhong 030600, China
- Publication Type:Research Article
- Keywords:
integrated pharmacology;
quality markers of traditional Chinese medicine;
in vitro pharmacology;
exact quantitative association;
component knockout technology;
biological effect;
Yuanhu Zhitong tablets
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(6):1-8
- CountryChina
- Language:Chinese
-
Abstract:
Quality marker(Q-marker) is a new concept and pattern for quality control of traditional Chinese medicine(TCM),which will lead the development direction for quality control of TCM.Among them,how to characterize the overall quality attribute of TCM and its biological effect,is a critical scientific problem in the study of Q-marker.In this paper,integrated pharmacology is utilized to screen out and confirm the Q-marker from the complex system of TCM,so as to solve the critical scientific problem.System biology in vivo is firstly applied to establish the correlation of chemical fingerprints of TCM,their metabolic fingerprints,network targets,biological effects and efficacy of TCM,which is used to preliminary screen out Q-marker of TCM.Following that,a pharmacological method in vitro,including intestinal absorption in vitro coupled with bioactivity assessment,is employed to simultaneously determine the absorbed doses of TCM and evaluate their biological activity.Furthermore,data mining is utilized to establish the exact quantitative mathematic model between Q-marker of TCM and bioactivity.Meanwhile,two representative examples,including Yuanhu Zhitong tablets,Xinsuning capsules,are introduced to identify Q-marker of TCM and establish their quality standards related with bioactivity,which will be beneficial to improve the level of quality control of TCM and ensure the effectiveness and safety of clinical applications.
